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CTNNB1 anticorps (C-Term)

CTNNB1 Reactivité: Humain WB, IF, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN951058
  • Antigène Voir toutes CTNNB1 Anticorps
    CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
    Épitope
    • 28
    • 17
    • 12
    • 12
    • 10
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 653-681, C-Term
    Reactivité
    • 228
    • 128
    • 113
    • 33
    • 24
    • 24
    • 19
    • 17
    • 12
    • 11
    • 11
    • 9
    • 8
    • 7
    • 6
    • 5
    • 1
    Humain
    Hôte
    • 153
    • 74
    • 3
    • 2
    Lapin
    Clonalité
    • 149
    • 83
    Polyclonal
    Conjugué
    • 196
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CTNNB1 est non-conjugé
    Application
    • 204
    • 96
    • 95
    • 76
    • 51
    • 48
    • 34
    • 33
    • 12
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody recognizes Human Catenin beta-1 (C-term).
    Purification
    Affinity Chromatography on Protein A
    Immunogène
    KLH conjugated synthetic peptide between 653-681 amino acids from the C-terminal region of Human Catenin beta-1. Genename: CTNNB1
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CTNNB1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS, 0.09 % Sodium Azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
  • Chairoungdua, Smith, Pochard, Hull, Caplan: "Exosome release of ?-catenin: a novel mechanism that antagonizes Wnt signaling." dans: The Journal of cell biology, Vol. 190, Issue 6, pp. 1079-91, (2010) (PubMed).

    Guo, Shen, Liao, Lian, Wang: "NGX6 inhibits cell invasion and adhesion through suppression of Wnt/beta-catenin signal pathway in colon cancer." dans: Acta biochimica et biophysica Sinica, Vol. 42, Issue 7, pp. 450-6, (2010) (PubMed).

    Mirza, Sun, Zhao, Potula, Frey, Vogel, Malik, Zhao: "FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression." dans: The Journal of experimental medicine, Vol. 207, Issue 8, pp. 1675-85, (2010) (PubMed).

    Teng, Wang, Wang, Wang: "[Effect of siRNA-mediated beta-catenin gene on Wnt signal pathway in lung adenocarcinoma A549 cell]." dans: Zhonghua yi xue za zhi, Vol. 90, Issue 14, pp. 988-92, (2010) (PubMed).

    Zhou, Sandercock, Fraser, Ridlova, Stephens, Schenauer, Yokoi-Fong, Barsky, Leary, Hershey, Doudna, Robinson: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, (2008) (PubMed).

  • Antigène
    CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
    Autre désignation
    Catenin beta-1 (CTNNB1 Produits)
    Synonymes
    anticorps Jup, anticorps LOC100217813, anticorps CTNNB1, anticorps CTNNB, anticorps Bfc, anticorps Catnb, anticorps Mesc, anticorps ctnnb, anticorps id:ibd2058, anticorps wu:fb73e10, anticorps wu:fi81c06, anticorps wu:fk25h01, anticorps ctnnb1, anticorps CHBCAT, anticorps MRD19, anticorps armadillo, anticorps beta-catenin, anticorps catenin beta 1, anticorps catenin (cadherin associated protein), beta 1, anticorps catenin (cadherin-associated protein), beta 1, anticorps catenin beta 1 S homeolog, anticorps catenin beta 1 L homeolog, anticorps CTNNB1, anticorps Ctnnb1, anticorps ctnnb1, anticorps ctnnb1.S, anticorps ctnnb1.L
    Sujet
    The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.Synonyms: Beta-catenin, CTNNB, CTNNB1
    Poids moléculaire
    85497 Da
    ID gène
    1499
    NCBI Accession
    NP_001091679
    Pathways
    Signalisation WNT, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
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