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CDT2/RAMP anticorps (Middle Region)

DTL Reactivité: Humain, Souris WB, FACS, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN951451
  • Antigène Voir toutes CDT2/RAMP (DTL) Anticorps
    CDT2/RAMP (DTL) (Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))
    Épitope
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 229-256, Middle Region
    Reactivité
    • 36
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 36
    Lapin
    Clonalité
    • 34
    • 2
    Polyclonal
    Conjugué
    • 21
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CDT2/RAMP est non-conjugé
    Application
    • 22
    • 14
    • 8
    • 5
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
    Specificité
    This antibody recognizes Human and Mouse CDT2 / DTL (Center).
    Purification
    Affinity Chromatography on Protein A
    Immunogène
    KLH conjugated synthetic peptide between 229-256 amino acids from the Central region of Human DTL.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product DTL Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) Sodium Azide as preservative
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Abbas, Sivaprasad, Terai, Amador, Pagano, Dutta: "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex." dans: Genes & development, Vol. 22, Issue 18, pp. 2496-506, (2008) (PubMed).

  • Antigène
    CDT2/RAMP (DTL) (Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))
    Autre désignation
    CDT2 / DTL (DTL Produits)
    Synonymes
    anticorps CDT2, anticorps DCAF2, anticorps L2DTL, anticorps RAMP, anticorps 2810047L02Rik, anticorps 5730564G15Rik, anticorps Ramp, anticorps RGD1310439, anticorps cdt2, anticorps cdt2-a, anticorps dcaf2, anticorps l2dtl, anticorps ramp, anticorps cb151, anticorps chunp6871, anticorps wu:fb54b02, anticorps denticleless E3 ubiquitin protein ligase homolog, anticorps denticleless E3 ubiquitin protein ligase, anticorps denticleless E3 ubiquitin protein ligase homolog S homeolog, anticorps denticleless E3 ubiquitin protein ligase homolog (Drosophila), anticorps DTL, anticorps Dtl, anticorps dtl.S, anticorps dtl
    Sujet
    Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.Synonyms: CDW1, DCAF2, Ddb1- and Cul4-associated factor 2, Denticleless protein homolog, L2DTL, Lethal(2) denticleless protein homolog, RA regulated Nuclear Matrix Associated Protein, RAMP, Retinoic acid-regulated nuclear matrix-associated protein
    Poids moléculaire
    79468 Da
    ID gène
    51514
    NCBI Accession
    NP_057532
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