HLA-DMB anticorps (Middle Region)

N° du produit ABIN952749

Détail du produit anti-HLA-DMB anticorps

Antigène: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Épitope: AA 103-133, Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-DMB est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody recognizes Human HLA class II DM beta / HLA-DMB (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogène: KLH conjugated synthetic peptide between 103-133 amino acids from the Central region of human HLA class II DM beta / HLA-DMB

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur HLA-DMB

Antigène: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Abstract: HLA-DMB Produits

Synonymes: anticorps RING7, anticorps D6S221E, anticorps RT1.DMb, anticorps RT1.Mb, anticorps MHC-DMB, anticorps major histocompatibility complex, class II, DM beta, anticorps RT1 class II, locus DMb, anticorps HLA-DMB, anticorps RT1-DMb, anticorps PATR-DMB

Sujet: HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.Synonyms: DMB, HLA class II histocompatibility antigen DM beta chain, MHC class II antigen DMB, RING7, Really interesting new gene 7 protein

Poids moléculaire: 28943 Da

ID gène: 3109

NCBI Accession: NP_002109

Pathways: Cancer Immune Checkpoints