RASGRP2 anticorps (N-Term)

N° du produit ABIN954463

Détail du produit anti-RASGRP2 anticorps

Antigène: RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2))

Épitope: AA 14-42, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RASGRP2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody recognizes Human RASGRP2 (N-term).

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat and Bovine.
Species reactivity (tested):Human.

Purification: Affinity Chromatography on Protein A

Immunogène: KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of Human RASGRP2. Genename: RASGRP2

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-RASGRP2 (ABIN954463)

Lima, Parreira, Devuyst, Caplanusi, Nkuli, Marien, Van Der Smissen, Alves, Verroust, Christensen, Terzi, Matter, Balda, Pierreux, Courtoy: "ZONAB promotes proliferation and represses differentiation of proximal tubule epithelial cells." dans: Journal of the American Society of Nephrology : JASN, Vol. 21, Issue 3, pp. 478-88, (2010) (PubMed).

Katagiri, Shimonaka, Kinashi: "Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1." dans: The Journal of biological chemistry, Vol. 279, Issue 12, pp. 11875-81, (2004) (PubMed).

Eto, Murphy, Kerrigan, Bertoni, Stuhlmann, Nakano, Leavitt, Shattil: "Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 20, pp. 12819-24, (2002) (PubMed).

Guo, Kumahara, Saffen: "A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2." dans: The Journal of biological chemistry, Vol. 276, Issue 27, pp. 25568-81, (2001) (PubMed).

Toki, Kawasaki, Tashiro, Housman, Graybiel: "Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons." dans: The Journal of comparative neurology, Vol. 437, Issue 4, pp. 398-407, (2001) (PubMed).

Détails sur RASGRP2

Antigène: RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2))

Autre désignation: RASGRP2 (RASGRP2 Produits)

Synonymes: anticorps CALDAG-GEFI, anticorps CDC25L, anticorps xrasgrp2, anticorps RASGRP2, anticorps Caldaggef1, anticorps CalDAG-GEFI, anticorps rasgrp2, anticorps RAS guanyl releasing protein 2, anticorps RAS guanyl releasing protein 2 (calcium and DAG-regulated) S homeolog, anticorps RAS, guanyl releasing protein 2, anticorps RAS guanyl releasing protein 2 (calcium and DAG-regulated) L homeolog, anticorps RASGRP2, anticorps rasgrp2.S, anticorps Rasgrp2, anticorps rasgrp2.L

Sujet: The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene.Synonyms: CDC25L, CalDAG-GEFI, Calcium and DAG-regulated guanine nucleotide exchange factor I, Cdc25-like protein, MCG7, RAS guanyl-releasing protein 2

Poids moléculaire: 75kd

ID gène: 10235

NCBI Accession: NP_001092140

Pathways: TCR Signaling