SREBF2 anticorps (Middle Region)
-
- Antigène Voir toutes SREBF2 Anticorps
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
-
Épitope
- AA 402-431, Middle Region
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp SREBF2 est non-conjugé
-
Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Specificité
- This antibody recognizes SREBF2 / SREBP2.
- Réactivité croisée (Details)
- Species reactivity (tested):Human
- Purification
- Purified through a Protein A column followed by peptide affinity purification
- Immunogène
- Synthetic peptide - KLH conjugated - corresponding to the central region (between 402-431aa) of human SREBF2 / SREBP2
- Isotype
- Ig Fraction
- Top Product
- Discover our top product SREBF2 Anticorps primaire
-
-
- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- PBS with 0.09 % (W/V) Sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- Antigène
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
- Autre désignation
- SREBF2 / SREBP2 (SREBF2 Produits)
- Synonymes
- anticorps SREBF2, anticorps srebp2, anticorps SREBP2, anticorps zgc:158371, anticorps AI608257, anticorps SREBP-2, anticorps SREBP2gc, anticorps bHLHd2, anticorps lop13, anticorps nuc, anticorps Srebf2_retired, anticorps sterol regulatory element binding transcription factor 2, anticorps sterol regulatory element binding factor 2, anticorps sterol regulatory element binding transcription factor 2 L homeolog, anticorps SREBF2, anticorps srebf2, anticorps Srebf2, anticorps srebf2.L
- Sujet
- SREBPs, including SREBP-1a, SREBP-1c, and SREBP-2, constitute a family of basic helix-loop-helix (bHLH) transcription factors that play a critical role in lipid homeostasis by regulating genes involved in cholesterol and fatty acid metabolism. Each SREBP consists of three domains, including an amino-terminal transcription factor domain of ~480 amino acids, a middle hydrophobic region of ~80 amino acids containing two hydrophobic transmembrane segments, and a carboxy-terminal regulatory domain of ~590 amino acids. SREBP-2 regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway. SREBP-2 is ubiquitously detected in various tissues. Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (about 50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol. LS-B1609 polyclonal antibody detects both precursor and active forms of the protein in tissues and cells such as liver, brown fat, testis, Hep-G2 cells, and human fibroblast. The apparent molecular weight on SDS-PAGE may be higher than the calculated molecular weight (about 126 kDa) due to glycosylation of the protein.Synonyms: BHLHD2, Class D basic helix-loop-helix protein 2, SREBP-2, Sterol regulatory element-binding protein 2, Sterol regulatory element-binding transcription factor 2
- ID gène
- 6721
- NCBI Accession
- NP_004590
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
-