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CTCF anticorps (C-Term)

CTCF Reactivité: Humain, Souris WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN964616
  • Antigène Voir toutes CTCF Anticorps
    CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
    Épitope
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 61
    • 39
    • 34
    • 8
    • 8
    • 7
    • 7
    • 5
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    Humain, Souris
    Hôte
    • 49
    • 10
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 39
    • 24
    Polyclonal
    Conjugué
    • 49
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CTCF est non-conjugé
    Application
    • 43
    • 12
    • 12
    • 10
    • 9
    • 9
    • 8
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificité
    This product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with endogenous CTCF protein. A BLAST analysis was used to suggest reactivity with CTCF from human, mouse, horse, bovine, panda, rabbit, Danio, and chicken based on a 100% homology with the immunizing sequence. Cross-reactivity with CTCF from other sources has not been determined.
     Réactivité croisée
    Souris
    Attributs du produit
    Transcriptional repressor CTCF (also known as CCCTC-binding factor) is a transcription factor encoded by the CTCF gene. The CTCF, and the closely related Brother of the Regulator of Imprinted Sites (BORIS), are highly conserved zinc finger proteins implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation. Expression of BORIS is restricted to spermatocytes and is mutually exclusive of CTCF expression. CTCF is ubiquitously expressed in higher eukaryotes and contains a highly conserved and eleven zinc finger central DNA-binding domain, having very high homology between mouse, chicken, and human and is embedded within slightly divergent N and C termini. CTFC plays a critical role in the epigenetic regulation and chromatin remodeling. CTCF has been reported to bind to a variety of DNA target sites that perform distinct functions, including promoter activation or repression, hormone-responsive gene silencing, methylation-dependent chromatin insulation, and genomic imprinting.
    Purification
    affinity purified
    Stérilité
    Sterile filtered
    Immunogène
    This affinity purified antibody was prepared by repeated immunizations with a synthetic peptide corresponding to a region near the C-terminus of CTCF protein.
    Immunogen Type: Peptide
    Isotype
    IgG
    Top Product
    Discover our top product CTCF Anticorps primaire
  • Indications d'application
    CTCF antibody is suitable for ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 82.8 kDa or 150 kDa in size corresponding to CTCF by western blotting in the appropriate cell lysate or extract.
    Commentaires

    Gene Name: CTCF

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.3 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
    Date de péremption
    12 months
  • Majumder, Rupp, Yang-Iott, Koues, Kyle, Bassing, Oltz: "Domain-Specific and Stage-Intrinsic Changes in Tcrb Conformation during Thymocyte Development." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 3, pp. 1262-72, (2015) (PubMed).

  • Antigène
    CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
    Autre désignation
    CTCF (CTCF Produits)
    Synonymes
    anticorps im:7152666, anticorps CTCF, anticorps xctcf, anticorps AW108038, anticorps CCCTC-binding factor, anticorps CCCTC-binding factor (zinc finger protein), anticorps CTCF, anticorps ctcf, anticorps Ctcf
    Sujet
    Transcriptional repressor CTCF (also known as CCCTC-binding factor) is a transcription factor encoded by the CTCF gene. The CTCF, and the closely related Brother of the Regulator of Imprinted Sites (BORIS), are highly conserved zinc finger proteins implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation. Expression of BORIS is restricted to spermatocytes and is mutually exclusive of CTCF expression. CTCF is ubiquitously expressed in higher eukaryotes and contains a highly conserved and eleven zinc finger central DNA-binding domain, having very high homology between mouse, chicken, and human and is embedded within slightly divergent N and C termini. CTFC plays a critical role in the epigenetic regulation and chromatin remodeling. CTCF has been reported to bind to a variety of DNA target sites that perform distinct functions, including promoter activation or repression, hormone-responsive gene silencing, methylation-dependent chromatin insulation, and genomic imprinting.
    Synonyms: Transcriptional repressor CTCF, 11-zinc finger protein, CCCTC-binding factor, CTCFL paralog
    ID gène
    10664
    NCBI Accession
    NP_006556
    UniProt
    P49711
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