BPTF anticorps

N° du produit ABIN965692

Détail du produit anti-BPTF anticorps

Antigène: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BPTF est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human BLNK expressed in E. Coli.

Clone: 2F10

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications. Determinine optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-BPTF (ABIN965692)

Imamura, Oda, Katahira, Bundo, Pike, Ratcliffe, Kitamura: "BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation." dans: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9804-13, (2009) (PubMed).

Kamino, Futamura, Nakamura, Kitamura, Kabu, Arakawa: "B-cell linker protein prevents aneuploidy by inhibiting cytokinesis." dans: Cancer science, Vol. 99, Issue 12, pp. 2444-54, (2008) (PubMed).

Détails sur BPTF

Antigène: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Autre désignation: BPTF (BPTF Produits)

Synonymes: anticorps FAC1, anticorps FALZ, anticorps NURF301, anticorps 9430093H17Rik, anticorps Falz, anticorps BPTF, anticorps bromodomain PHD finger transcription factor, anticorps nucleosome-remodeling factor subunit NURF301, anticorps fetal alzheimer antigen, falz, anticorps BPTF, anticorps Bptf, anticorps LOC5576547, anticorps CpipJ_CPIJ011285, anticorps bptf

Sujet: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: AGM4, BASH, LY57, SLP65, BLNKS, SLP-65, MGC111051

Poids moléculaire: 68kDa

ID gène: 2186