DDC anticorps (C-Term)

N° du produit ABIN965981

Détail du produit anti-DDC anticorps

Antigène: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDC est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human DDC (Netrin receptor DCC precursor) (Tumor suppressor protein DCC)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur DDC

Antigène: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Autre désignation: DDC (DDC Produits)

Synonymes: anticorps AADC, anticorps wu:fa56d05, anticorps wu:fd59h03, anticorps wu:fk20h01, anticorps zgc:65801, anticorps zgc:76929, anticorps Ddc, anticorps DdcDv, anticorps Dvir\\GJ17995, anticorps GJ17995, anticorps dvir_GLEANR_2561, anticorps Aadc, anticorps 5-HT, anticorps CG10697, anticorps DDC, anticorps DdcDm, anticorps Dmel\\CG10697, anticorps ddc, anticorps fDDC, anticorps l(2)37Bl, anticorps l(2)37Ch, anticorps l(2)k02104, anticorps dopa decarboxylase, anticorps Dopa-decarboxylase, anticorps dopa decarboxylase (aromatic L-amino acid decarboxylase), anticorps Dopa decarboxylase, anticorps dopa decarboxylase L homeolog, anticorps DDC, anticorps ddc, anticorps Ddc, anticorps Dvir\Ddc, anticorps ddc.L

Sujet: DDC (Netrin receptor DCC) (Tumor suppressor protein DCC) is a receptor for netrin required for axon guidance. It mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. The protein implicated as a tumor suppressor gene. It interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D (By similarity). Colorectal tumors that lost their capacity to differentiate into mucus producing cells uniformly lack DCC expression. Inactivation of DCC due to allelic deletion and/or point mutations may cause both lymphatic and hematogenous metastasis of esophageal squamous cell carcinomas.

Pathways: Dopaminergic Neurogenesis