Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Réactivité croisée
Souris, Rat (Rattus)
Réactivité croisée (Details)
No cross reactivity with other proteins.
Attributs du produit
Rabbit IgG polyclonal antibody for Heat shock protein HSP 90-alpha (HSP90AA1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Immunogène
A synthetic peptide corresponding to a sequence at the C-terminal of human HSP90 , identical to the related mouse and rat sequence.< br/>Immunogen was affinity purified.
At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Chen, Zhong, Monteiro: "Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms." dans: BMC genomics, Vol. 7, pp. 156, (2006) (PubMed).
Csermely, Schnaider, Soti, Prohászka, Nardai: "The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review." dans: Pharmacology & therapeutics, Vol. 79, Issue 2, pp. 129-68, (1998) (PubMed).
Antigène
HSP90AA1
(Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 1 (HSP90AA1))
anticorps EL52, anticorps HSP86, anticorps HSP89A, anticorps HSP90A, anticorps HSP90N, anticorps HSPC1, anticorps HSPCA, anticorps HSPCAL1, anticorps HSPCAL4, anticorps HSPN, anticorps Hsp89, anticorps Hsp90, anticorps LAP2, anticorps Hsp86, anticorps Hspca, anticorps htpG, anticorps 86kDa, anticorps 89kDa, anticorps AL024080, anticorps AL024147, anticorps Hsp86-1, anticorps hsp4, anticorps HSP90, anticorps HSP90AA1, anticorps fb17b01, anticorps hsp90, anticorps hsp90a, anticorps hsp90a.1, anticorps hsp90alpha, anticorps wu:fb17b01, anticorps zgc:86652, anticorps Hsp90alpha, anticorps heat shock protein 90 alpha family class A member 1, anticorps heat shock protein 90, alpha (cytosolic), class A member 1, anticorps Heat Shock Protein 90, cytosolic, anticorps heat shock protein 90A, anticorps molecular chaperone, anticorps heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1, anticorps heat shock protein HSP 90-alpha, anticorps heat shock protein 90kDa alpha (cytosolic), class A member 1, anticorps HSP90AA1, anticorps Hsp90aa1, anticorps HSP90A, anticorps hsp90A, anticorps hsp90aa1.1, anticorps LOC108698781
Sujet
Hsp90 (heat shock protein 90) is a molecular chaperone and is one of the most abundant proteins expressed in cells. It is a member of the heat shock protein family which is upregulated in response to stress. Hsp90 is found in bacteria and all branches of eukarya, but it is apparently absent in archaea. Cytoplasmic Hsp90 is essential for viability under all conditions in eukaryotes, the bacterial homologue HtpG is dispensable under non-heat stress conditions. The function of Hsp90 includes assisting in protein folding, cell signaling, and tumor repression. This protein was first isolated by extracting proteins from stressed cells. These cells were stressed by heating, dehydrating or by other means, all of which caused the cell�s proteins to begin to denature. Researchers later realized that Hsp90 has other essential functions in unstressed cells.