NFKB1 anticorps (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1)

Details for Product anti-NFKB1 Antibody No. ABIN966668, Fournisseur: Connectez-vous pour afficher
Antigène
  • EBP-1
  • KBF1
  • NF-kB1
  • NF-kappa-B
  • NF-kappaB
  • NFKB-p105
  • NFKB-p50
  • NFkappaB
  • p105
  • p50
  • NF-kB
  • NF-KB1
  • ebp-1
  • kbf1
  • nf-kappa-b
  • nf-kappaB
  • nfkb-p105
  • nfkb-p50
  • NF-kappaB1
  • p50/p105
  • BICDR-1
  • bicdr1
  • ccdc64
  • nuclear factor kappa B subunit 1
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 L homeolog
  • nuclear factor NF-kappa-B p105 subunit
  • nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  • NFKB1
  • Nfkb1
  • nfkb1.L
  • CpipJ_CPIJ012236
  • nfkb1
Reactivité
Humain
605
234
190
24
21
18
16
5
5
4
3
2
1
1
1
Hôte
Souris
553
75
2
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp NFKB1 est non-conjugé
16
16
13
8
8
6
6
6
6
6
6
6
6
6
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
515
317
192
158
139
80
64
34
27
20
11
7
4
4
3
2
1
1
Options
Fournisseur
Connectez-vous pour afficher
N° du produit (Fournisseur)
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Immunogène Purified recombinant fragment of human NFKB1 expressed in E. Coli.
Clone 5D10D11
Isotype IgG2a
Purification Ascitic fluid
Plasmids, Primers & others Plasmids, Primers & others NFKB1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation NFKB1 (NFKB1 Antibody Extrait)
Sujet This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms: p50, KBF1, p105, EBP1, MGC54151, NFKB-p50, NFkappaB, NF-kappaB, NFKBp105, NF-kappa-B
Poids moléculaire 50kDa/105kDa
ID gène 4790
Pathways Signalisation p53, Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Toll-Like Receptors Cascades
Indications d'application Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Background publications Endo, Kinouchi, Kakuta, Ueki, Takahashi, Shimosegawa: "Involvement of NF-kappa B pathway in TL1A gene expression induced by lipopolysaccharide." dans: Cytokine, Vol. 49, Issue 2, pp. 215-20, 2010 (PubMed).

Burnik, Yalçin: "NFKB1 -94 insertion/deletion ATTG polymorphism in gastroenteropancreatic neuroendocrine tumors." dans: Chemotherapy, Vol. 55, Issue 5, pp. 381-5, 2009 (PubMed).

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