Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1) (C-Term) anticorps

Détails pour le produit réf. ABIN966708, Fournisseur: Connectez-vous pour afficher
Antigène
  • SLC22A1
  • OCT1
  • HOCT1
  • oct1_cds
  • Lx1
  • Oct1
  • Orct
  • Orct1
  • Roct1
  • SLC22A2
  • solute carrier family 22 member 1
  • solute carrier family 22 (organic cation transporter), member 1
  • solute carrier family 22 member 2-like
  • SLC22A1
  • Slc22a1
  • LOC421584
Épitope
C-Term
21
11
7
5
4
3
2
2
2
1
1
1
1
Reactivité
Humain
96
23
19
7
6
5
4
2
2
2
1
1
Hôte
Lapin
74
20
3
Clonalité
Polyclonal
Conjugué
Inconjugué
4
4
3
2
2
2
Application
Immunohistochemistry (IHC)
86
51
41
17
14
5
4
3
2
1
Options
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Immunogène Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human OCT1 (Organic cation transporter 1)
Autre désignation OCT1 (SLC22A1 Antibody Extrait)
Sujet OCT1 (Organic cation transporter 1) translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine.Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase. OCT1 is widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines. In the liver activated by HNF4A and suppressed by bile acids via NR0B2. Increased by cholesterol treatment in hepatocyte cells. OCT1 belongs to the major facilitator superfamily and organic cation transporter family.
Synonyms: SLC22A1(Solute carrier family 22 member 1)
Pathways Hormone Transport
Restrictions For Research Use only
Produit citée dans: Hayer, Bönisch, Brüss: "Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1)." dans: Annals of human genetics, Vol. 63, Issue Pt 6, pp. 473-82, 2001 (PubMed).

Gorboulev, Ulzheimer, Akhoundova, Ulzheimer-Teuber, Karbach, Quester, Baumann, Lang, Busch, Koepsell: "Cloning and characterization of two human polyspecific organic cation transporters." dans: DNA and cell biology, Vol. 16, Issue 7, pp. 871-81, 1997 (PubMed).

Zhang, Dresser, Gray, Yost, Terashita, Giacomini: "Cloning and functional expression of a human liver organic cation transporter." dans: Molecular pharmacology, Vol. 51, Issue 6, pp. 913-21, 1997 (PubMed).

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