OCT4 anticorps (POU Class 5 Homeobox 1)

Details for Product anti-POU5F1 Antibody No. ABIN966711, Fournisseur: Connectez-vous pour afficher
Antigène
  • OCT3
  • OCT4
  • OTF-3
  • OTF3
  • OTF4
  • Oct-3
  • Oct-4
  • POU5F1
  • gp9
  • gp-9
  • oct4
  • pou2
  • POU-2
  • cb197
  • spg/pou2
  • chunp6868
  • wu:fd18d06
  • NF-A3
  • Oct-3/4
  • Oct3
  • Oct3/4
  • Oct4
  • Otf-3
  • Otf-4
  • Otf3
  • Otf3-rs7
  • Otf3g
  • Otf4
  • POU class 5 homeobox 1
  • POU domain, class 5, transcription factor 3
  • POU domain, class 5, transcription factor 1
  • POU5F1
  • pou5f3
  • Pou5f1
Reactivité
Humain
396
176
68
25
17
14
13
13
9
6
5
2
2
2
2
1
1
1
1
Hôte
Souris
226
147
32
31
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp OCT4 est non-conjugé
18
14
12
12
11
8
7
6
5
5
4
4
3
3
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
332
176
111
107
78
74
48
18
17
13
7
6
4
3
3
3
2
2
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Synthesized peptide of human Oct4.
Clone 5F7
Isotype IgG1
Purification Ascitic fluid
Autre désignation Oct4 (POU5F1 Antibody Extrait)
Sujet This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6,22)(p21,q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a nonAUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12..
Tissue specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.
Synonyms: OCT3, OCT4, OTF3, OTF4, OTF-3, Oct-3, Oct-4, MGC22487, POU5F1
Poids moléculaire 45kDa
ID gène 5460
Pathways Stem Cell Maintenance
Indications d'application Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Background publications Zhang, Zhang, Wang, Esteban, Pei: "Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells." dans: The Journal of biological chemistry, Vol. 283, Issue 51, pp. 35825-33, 2008 (PubMed).

Cha, Sung, Jung, Kim, Lee, Park: "Epigenetic deregulation of the human Oct4 promoter in mouse cells." dans: Development genes and evolution, Vol. 218, Issue 10, pp. 561-6, 2008 (PubMed).

Produit citée dans: Kaltz, Funari, Hippauf, Delorme, Noël, Riminucci, Jacobs, Häupl, Jorgensen, Charbord, Peschel, Bianco, Oostendorp: "In vivo osteoprogenitor potency of human stromal cells from different tissues does not correlate with expression of POU5F1 or its pseudogenes." dans: Stem cells (Dayton, Ohio), Vol. 26, Issue 9, pp. 2419-24, 2008 (PubMed).

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