P-Cadherin (AA 612-626) anticorps

Détails pour le produit réf. ABIN966724, Fournisseur: Connectez-vous pour afficher
Antigène
  • CDH3
  • Cadherin-3
  • AI385538
  • Cadp
  • Cdhp
  • P-cadherin
  • Pcad
  • CDHP
  • HJMD
  • PCAD
  • E-Cad
  • E-cadherin
  • EP-cadherin
  • XTCAD-1
  • c-cadherin
  • cadherin-1
  • cdh1
  • cdh1-b
  • cdh3
  • cdhc-A
  • cdhp
  • hjmd
  • l-cam
  • lcam
  • pcad
  • uvo
  • uvomorulin
  • xb-cad
  • xcdh1
  • CDH15
  • K-CAM
  • cadherin 3
  • cadherin 3 L homeolog
  • Cadherin-3
  • CDH3
  • Cdh3
  • cdh3.L
  • cdh-3
Épitope
AA 612-626
17
15
13
11
11
8
7
7
7
5
5
5
4
4
2
2
2
1
1
1
Reactivité
Humain
270
67
26
1
1
1
1
1
Hôte
146
129
13
3
Clonalité
Polyclonal
Conjugué
Inconjugué
16
13
11
11
11
7
7
6
6
6
5
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
224
153
105
98
57
49
27
18
13
12
9
8
4
3
3
2
1
1
1
Options
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Immunogène A synthetic peptide corresponding to a sequence at the middle region of human P-Cadherin (612-626 aa), different from the mouse and rat sequence by one amino acid.
Antigène
Sujet Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.
Indications d'application WB: The detection limit for P-Cadherin is approximately 2.5ng/lane under non-reducing and reducing conditions.
Restrictions For Research Use only
Reconstitution 0.2ml of distilled water will yield a concentration of 500µg/ml.
Buffer Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
Agent conservateur Thimerosal (Merthiolate), Sodium azide
Stock -20 °C
Produit citée dans: Kaupmann, Becker-Follmann, Scherer, Jockusch, Starzinski-Powitz: "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species." dans: Genomics, Vol. 14, Issue 2, pp. 488-90, 1992 (PubMed).

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