p53 anticorps (Tumor Protein P53) (pSer315)

Details for Product anti-TP53 Antibody No. ABIN966756, Fournisseur: Connectez-vous pour afficher
Antigène
  • BCC7
  • LFS1
  • P53
  • TRP53
  • p53
  • Trp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • tp53
  • Xp53
  • TP53
  • tumor protein p53
  • cellular tumor antigen p53
  • transformation related protein 53
  • tumor protein p53 L homeolog
  • TP53
  • CpipJ_CPIJ002758
  • Tp53
  • tp53
  • Trp53
  • tp53.L
Épitope
pSer315
167
124
77
74
72
70
65
59
59
55
45
43
41
36
35
35
33
25
24
24
23
22
21
21
17
15
15
15
15
15
15
15
14
13
13
12
11
10
9
8
8
8
8
7
7
7
7
7
7
7
6
6
6
6
6
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
2493
562
464
293
156
104
103
61
55
26
23
23
18
17
16
14
7
6
5
4
4
4
4
3
3
3
2
1
1
Hôte
Lapin
1482
1130
7
5
1
1
1
1
Conjugué
Cet anticorp p53 est non-conjugé
80
79
67
52
45
36
34
32
23
23
21
20
19
19
19
19
18
18
18
18
15
14
14
12
12
12
12
12
11
8
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
6
5
2
2
2
Application
Immunohistochemistry (IHC)
2069
943
868
761
662
653
421
292
259
155
110
90
75
41
33
18
17
15
13
6
4
4
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène The antiserum was produced against synthesized phosphopeptide derived from human p53 around the phosphorylation site of serine 315 (S-S-SP-P-Q).
Specificité P53 (phospho-Ser315) antibody detects endogenous levels of p53 only when phosphorylated at serine 315.
Plasmids, Primers & others Plasmids, Primers & others p53 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation p53 (TP53 Antibody Extrait)
Pathways Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Background publications Pospísilová, Brázda, Kucharíková, Luciani, Hupp, Skládal, Palecek, Vojtesek: "Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2." dans: The Biochemical journal, Vol. 378, Issue Pt 3, pp. 939-47, 2004 (PubMed).

Lu, Fisher, Bailey, Levine: "The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro." dans: Molecular and cellular biology, Vol. 17, Issue 10, pp. 5923-34, 1997 (PubMed).

Lohrum, Scheidtmann: "Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes." dans: Oncogene, Vol. 13, Issue 12, pp. 2527-39, 1997 (PubMed).

Ullrich, Sakaguchi, Lees-Miller, Fiscella, Mercer, Anderson, Appella: "Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 13, pp. 5954-8, 1993 (PubMed).

Produit citée dans: Merrick, Zhou, Martin, Jeyarajah, Parker, Selkirk, Tomer, Borchers: "Site-specific phosphorylation of human p53 protein determined by mass spectrometry." dans: Biochemistry, Vol. 40, Issue 13, pp. 4053-66, 2001 (PubMed).

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