p53 anticorps (Tumor Protein P53) (pSer315)

Details for Product anti-TP53 Antibody No. ABIN966756, Fournisseur: Connectez-vous pour afficher
Antigène
  • BCC7
  • LFS1
  • P53
  • TRP53
  • p53
  • Trp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • tp53
  • Xp53
  • TP53
  • tumor protein p53
  • cellular tumor antigen p53
  • transformation related protein 53
  • tumor protein p53 L homeolog
  • TP53
  • CpipJ_CPIJ002758
  • Tp53
  • tp53
  • Trp53
  • tp53.L
Épitope
pSer315
191
122
89
86
79
72
67
59
57
53
50
47
47
44
43
35
34
33
26
23
22
22
21
20
17
15
15
15
15
15
14
14
12
12
11
11
11
11
10
9
9
8
7
7
7
7
7
7
6
6
6
6
6
6
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
2440
533
449
194
119
93
83
83
33
23
20
20
19
16
15
14
6
4
4
4
3
3
3
2
1
1
Hôte
Lapin
1424
1135
7
1
1
1
1
Conjugué
Cet anticorp p53 est non-conjugé
85
81
67
54
47
46
45
31
31
28
25
25
25
25
25
24
24
24
20
19
18
14
14
14
14
14
12
7
7
7
7
7
7
7
7
7
6
5
2
2
2
Application
Immunohistochemistry (IHC)
1988
895
849
738
624
623
437
340
306
179
90
77
41
30
21
17
17
15
13
9
9
4
4
3
3
3
2
1
1
1
1
1
1
1
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène The antiserum was produced against synthesized phosphopeptide derived from human p53 around the phosphorylation site of serine 315 (S-S-SP-P-Q).
Specificité P53 (phospho-Ser315) antibody detects endogenous levels of p53 only when phosphorylated at serine 315.
Autre désignation p53 (TP53 Antibody Extrait)
Pathways Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Background publications Pospísilová, Brázda, Kucharíková, Luciani, Hupp, Skládal, Palecek, Vojtesek: "Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2." dans: The Biochemical journal, Vol. 378, Issue Pt 3, pp. 939-47, 2004 (PubMed).

Lu, Fisher, Bailey, Levine: "The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro." dans: Molecular and cellular biology, Vol. 17, Issue 10, pp. 5923-34, 1997 (PubMed).

Lohrum, Scheidtmann: "Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes." dans: Oncogene, Vol. 13, Issue 12, pp. 2527-39, 1997 (PubMed).

Ullrich, Sakaguchi, Lees-Miller, Fiscella, Mercer, Anderson, Appella: "Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 13, pp. 5954-8, 1993 (PubMed).

Produit citée dans: Merrick, Zhou, Martin, Jeyarajah, Parker, Selkirk, Tomer, Borchers: "Site-specific phosphorylation of human p53 protein determined by mass spectrometry." dans: Biochemistry, Vol. 40, Issue 13, pp. 4053-66, 2001 (PubMed).

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