P55,50 (Epstein-Barr Virus Early Antigen) anticorps

Détails pour le produit réf. ABIN966761, Fournisseur: Connectez-vous pour afficher
Antigène
Reactivité
Humain
Hôte
Souris
Clonalité (Clone)
Monoclonal ()
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Immunogène Immunoprecipitated EBV early antigens
Clone B485
Isotype IgG1
Specificité This antibody reacts with a polypeptide of 50,55 kD associated with early antigen of the Epstein-Barr virus (EBV). p55 is a phosphoprotein and p55,50 binds to single-stranded DNA more readily than to dsDNA.EBV causes mononucleosis and is associated with both Burkitt's lymphoma and nasopharyngeal carcinoma. The early antigen is the first detectable marker of EBV infection.
Purification Concentrated.
Poids moléculaire 50-55 kDa
Indications d'application Immunohistochemistry: 1:50-1:100.
Staining Procedure: This antibody can be used on frozen and formalin-fixed paraffin-embedded tissue sections. When using on formalin-fixed paraffinembedded tissue sections an antigen demasking procedure is highly recommended. The antibody may be used at a dilution of 1:50-1:100 in IHC. The optimal conditions should be determined by the individual laboratory.
Commentaires

Cellular Localization: Nuclear.
Recommended Positive Control: Raji Granulocytess

Restrictions For Research Use only
Format Liquid
Concentration 0.3 mg/ml.
Buffer 20 mM tris-borate, 150 mM Sodium Chloride, dialyzed media RPMI 1640/D-MEM containing fetal bovine serum, BMC-6 carrier polysaccharides, carrier protein, pH 7.5
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Background publications Rowe, Rowe, Gregory, Young, Farrell, Rupani, Rickinson: "Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells." dans: The EMBO journal, Vol. 6, Issue 9, pp. 2743-51, 1988 (PubMed).

Rowe, Evans, Young, Hennessy, Kieff, Rickinson: "Monoclonal antibodies to the latent membrane protein of Epstein-Barr virus reveal heterogeneity of the protein and inducible expression in virus-transformed cells." dans: The Journal of general virology, Vol. 68 ( Pt 6), pp. 1575-86, 1987 (PubMed).

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