P21-Activated Kinases 1/2/3 (PAK1/2/3) (pThr402), (pThr421), (pThr423) anticorps

Détails pour le produit réf. ABIN966798, Fournisseur: Connectez-vous pour afficher
Antigène
  • X-PAK1
  • XPak1
  • pak
  • pak-1
  • pakalpha
  • p21 protein (Cdc42/Rac)-activated kinase 1 S homeolog
  • p21 (RAC1) activated kinase 1
  • pak1.S
  • PAK1
Épitope
pThr423, pThr402, pThr421
28
23
14
7
7
6
6
6
5
5
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
67
52
48
2
2
1
Hôte
Lapin
71
Clonalité
Polyclonal
Conjugué
Inconjugué
1
Application
Immunohistochemistry (IHC)
51
40
33
17
13
4
2
2
1
Options
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Immunogène The antiserum was produced against synthesized phosphopeptide derived from human PAK1 around the phosphorylation site of threonine 423 (R-S-TP-M-V).
Specificité PAK1/PAK2/PAK3 (Phospho-Thr423/Thr402/Thr421) antibody detects endogenous levels of PAK1/PAK2/PAK3 only when phosphorylated at threonine 423/402/421.
Antigène
Autre désignation PAK1/PAK2/PAK3 (PAK1/2/3 Antibody Extrait)
Indications d'application IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Background publications Parsons, Monypenny, Ameer-Beg, Millard, Machesky, Peter, Keppler, Schiavo, Watson, Chernoff, Zicha, Vojnovic, Ng: "Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells." dans: Molecular and cellular biology, Vol. 25, Issue 5, pp. 1680-95, 2005 (PubMed).

Jung, Traugh: "Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141." dans: The Journal of biological chemistry, Vol. 280, Issue 48, pp. 40025-31, 2005 (PubMed).

Lampugnani, Zanetti, Breviario, Balconi, Orsenigo, Corada, Spagnuolo, Betson, Braga, Dejana: "VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam." dans: Molecular biology of the cell, Vol. 13, Issue 4, pp. 1175-89, 2002 (PubMed).

Produit citée dans: Wang, Mazumdar, Vadlamudi, Kumar: "P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium." dans: The EMBO journal, Vol. 21, Issue 20, pp. 5437-47, 2002 (PubMed).

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