PARL anticorps (Presenilin Associated, Rhomboid-Like) (AA 112-167)

Details for Product anti-PARL Antibody No. ABIN966805, Fournisseur: Connectez-vous pour afficher
Antigène
  • PSARL
  • PSARL1
  • PSENIP2
  • RHBDS1
  • D16Ertd607e
  • PRO2207
  • Psarl
  • presenilin associated rhomboid like
  • presenilin associated, rhomboid-like
  • PARL
  • Parl
Épitope
AA 112-167
13
7
4
2
2
1
1
1
1
Reactivité
Humain
46
22
21
4
4
3
2
2
2
1
1
1
1
1
Hôte
Souris
32
13
2
Clonalité (Clone)
Monoclonal ()
Application
ELISA, Western Blotting (WB)
40
28
18
8
7
7
2
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Purified recombinant fragment of PARL (aa112-167) expressed in E. Coli.
Clone 8C4B2-1H12E10
Isotype IgG2b
Purification Ascitic fluid
Plasmids, Primers & others Plasmids, Primers & others PARL products on genomics-online (e.g. as negative or positive controls)
Autre désignation PARL (PARL Antibody Extrait)
Sujet PARL: presenilin associated, rhomboid-like. This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms: PSARL, PSARL1, RHBDS1
ID gène 55486
Indications d'application Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Background publications McQuibban, Saurya, Freeman: "Mitochondrial membrane remodelling regulated by a conserved rhomboid protease." dans: Nature, Vol. 423, Issue 6939, pp. 537-41, 2003 (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Produit citée dans: Pellegrini, Passer, Canelles, Lefterov, Ganjei, Fowlkes, Koonin, DAdamio: "PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2." dans: Journal of Alzheimer's disease : JAD, Vol. 3, Issue 2, pp. 181-190, 2002 (PubMed).

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