PAX8 anticorps (Paired Box 8)

Details for Product anti-PAX8 Antibody No. ABIN966806, Fournisseur: Connectez-vous pour afficher
Antigène
  • PAX8
  • XPax-8
  • XPax8
  • pax-8
  • PAX-8
  • Pax-8
  • paired box 8
  • paired box 8 L homeolog
  • PAX8
  • pax8
  • Pax8
  • pax8.L
Reactivité
Humain
262
48
48
13
9
9
8
7
5
4
3
2
1
Hôte
Souris
137
87
38
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp PAX8 est non-conjugé
11
9
8
8
8
6
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
ELISA, Western Blotting (WB)
234
104
103
99
81
53
47
24
4
3
3
2
2
1
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Purified recombinant fragment of human PAX8 expressed in E. Coli.
Clone 2D4
Isotype IgG1
Purification Ascitic fluid
Plasmids, Primers & others Plasmids, Primers & others PAX8 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation PAX8 (PAX8 Antibody Extrait)
Sujet This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas.
Tissue specificity: Expressed in the excretory system, thyroid gland and Wilms tumors.ABCAM: This protein is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain, an octapeptide, and a paired-type homeodomain. This family plays critical roles during fetal development and cancer growth. The specific function of the PAX8 is unknown but it may involve kidney cell differentiation, thyroid development, or thyroid dysgenesis. Alternative splicing in the gene by inclusion or exclusion of exons 7 and/or 8 has produced several known products but the biological significance of the variants is unknown. Several other splice variants have been proposed but the full nature of these products has not been described. Pax8 is also a marker of otic progenitor cells.
Synonyms: PAX8
Poids moléculaire 60kDa
ID gène 7846
Pathways Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Stem Cell Maintenance, Tube Formation
Indications d'application Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Produit citée dans: McKnight, Cohen, Siddiqui: "Utility of paired box gene 8 (PAX8) expression in fluid and fine-needle aspiration cytology: an immunohistochemical study of metastatic ovarian serous carcinoma." dans: Cancer cytopathology, Vol. 118, Issue 5, pp. 298-302, 2010 (PubMed).

Chia, Sharifah, Reena, Zubaidah, Clarence-Ko, Rohaizak, Naqiyah, Srijit, Hisham, Asmiati, Rafie: "Fluorescence in situ hybridization analysis using PAX8- and PPARG-specific probes reveals the presence of PAX8-PPARG translocation and 3p25 aneusomy in follicular thyroid neoplasms." dans: Cancer genetics and cytogenetics, Vol. 196, Issue 1, pp. 7-13, 2009 (PubMed).

Background publications Ramos, Nesi-França, Boldarine, Pereira, Chiamolera, Camacho, Graf, de Lacerda, Carvalho, Maciel: "Clinical and molecular analysis of thyroid hypoplasia: a population-based approach in southern Brazil." dans: Thyroid : official journal of the American Thyroid Association, Vol. 19, Issue 1, pp. 61-8, 2009 (PubMed).

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