PDGFRB anticorps

N° du produit ABIN966814

Détail du produit anti-PDGFRB anticorps

Antigène: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PDGFRB est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human PDGFR-beta expressed in E. Coli.

Clone: 1A2

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-PDGFRB (ABIN966814)

Gredmark, Strååt, Homman-Loudiyi, Kannisto, Söderberg-Nauclér: "Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells." dans: Journal of virology, Vol. 81, Issue 10, pp. 5112-20, (2007) (PubMed).

Ferguson: "Melanoma." dans: Journal of continuing education in nursing, Vol. 36, Issue 6, pp. 242-3, (2005) (PubMed).

Wilczynski, Chen, Chen, Howell, Shively, Alberts: "Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers." dans: Human pathology, Vol. 36, Issue 3, pp. 242-9, (2005) (PubMed).

Hansen, Rönnstrand, Rorsman, Hellman, Heldin: "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor." dans: Biochemical and biophysical research communications, Vol. 235, Issue 3, pp. 455-60, (1997) (PubMed).

Détails sur PDGFRB

Antigène: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Autre désignation: PDGFRbeta (PDGFRB Produits)

Synonymes: anticorps AI528809, anticorps CD140b, anticorps PDGFR-1, anticorps Pdgfr, anticorps CD140B, anticorps IBGC4, anticorps JTK12, anticorps PDGFR, anticorps PDGFR1, anticorps platelet derived growth factor receptor, beta polypeptide, anticorps platelet derived growth factor receptor beta, anticorps Pdgfrb, anticorps PDGFRB

Sujet: Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFRbeta or CD140B. It is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. This family exist as several disulphidebonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor alpha (PDGFRalpha) and PDGF receptor beta (PDGFRbeta). These growth factors are mitogens for cells of mesenchymal origin. PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colonystimulating factor and macrophage-colony stimulating factor receptor, all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Synonyms: JTK12, PDGFR, CD140B, PDGFR1, PDGFRB

Poids moléculaire: 190kDa

ID gène: 5159

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling