PLAUR anticorps (Plasminogen Activator, Urokinase Receptor) (C-Term)

Details for Product anti-PLAUR Antibody No. ABIN966859, Fournisseur: Connectez-vous pour afficher
Antigène
  • PLAUR
  • u-PAR
  • Cd87
  • uPAR
  • CD87
  • U-PAR
  • UPAR
  • URKR
  • Par
  • Plaur3
  • uPAR-2
  • uPAR-3
  • plasminogen activator, urokinase receptor
  • PLAUR
  • Plaur
Épitope
C-Term
14
9
8
8
7
7
5
4
4
4
4
4
4
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
Reactivité
Humain
162
77
48
1
1
Hôte
Lapin
109
75
29
14
8
Clonalité
Polyclonal
Conjugué
Cet anticorp PLAUR est non-conjugé
17
16
14
11
5
5
5
3
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
140
65
64
57
22
18
17
13
9
9
6
5
5
4
3
1
1
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène A synthetic peptide corresponding to a sequence at the C-terminal of human PLAUR.< br/>Immunogen was affinity purified.
Isotype IgG
Réactivité croisée (Details) No cross reactivity with other proteins.
Attributs du produit Rabbit IgG polyclonal antibody for Urokinase plasminogen activator surface receptor (PLAUR) detection. Tested with WB, IHC-P in Human.
Plasmids, Primers & others Plasmids, Primers & others PLAUR products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Urokinase plasminogen activator surface receptor(U-PAR/uPAR) (PLAUR Antibody Extrait)
Sujet PLAUR (PLASMINOGEN ACTIVATOR RECEPTOR, UROKINASE-TYPE), also known as UPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor. PLAUR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. PLAUR is originally identified as a saturable binding site for urokinase on the cell surface. And the gene plays an important role in many normal as well as pathologic processes. The PLAUR gene is localized to 19q13. 31. PLAUR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. PLAUR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. Thus it seems to be an important player in the regulation of this process. In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a UPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase.
Pathways Inositol Metabolic Process
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Agent conservateur Sodium azide, Thimerosal (Merthiolate)
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock -20 °C
Stockage commentaire At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
Produit citée dans: Wang, Yang, Jamaluddin, Boyd: "The Kruppel-like KLF4 transcription factor, a novel regulator of urokinase receptor expression, drives synthesis of this binding site in colonic crypt luminal surface epithelial cells." dans: The Journal of biological chemistry, Vol. 279, Issue 21, pp. 22674-83, 2004 (PubMed).

Vagnarelli, Raimondi, Mazzieri, De Carli, Mignatti: "Assignment of the human urokinase receptor gene (PLAUR) to 19q13." dans: Cytogenetics and cell genetics, Vol. 60, Issue 3-4, pp. 197-9, 1992 (PubMed).

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