PTK2B anticorps (PTK2B Protein tyrosine Kinase 2 beta) (AA 815-997)

Details for Product anti-PTK2B Antibody No. ABIN966925, Fournisseur: Connectez-vous pour afficher
Antigène
  • CADTK
  • CAKB
  • FADK2
  • FAK2
  • PKB
  • PTK
  • PYK2
  • RAFTK
  • CAKbeta
  • E430023O05Rik
  • Raftk
  • Pyk2
  • fak1b
  • ptk2.2
  • ptk2b
  • si:ch1073-355e8.1
  • protein tyrosine kinase 2 beta
  • PTK2 protein tyrosine kinase 2 beta
  • protein tyrosine kinase 2aa
  • PTK2B
  • Ptk2b
  • ptk2aa
Épitope
AA 815-997
56
21
15
15
15
13
11
10
9
8
7
7
7
5
5
5
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
273
183
159
12
11
9
7
7
7
5
2
1
1
1
Hôte
Souris
233
42
3
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp PTK2B est non-conjugé
7
7
6
4
3
3
3
3
3
3
3
3
3
3
3
2
2
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
214
141
115
58
39
24
21
6
5
3
2
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.
Clone 5E2D5
Isotype IgG2a
Purification Ascitic fluid
Autre désignation PYK2 (PTK2B Antibody Extrait)
Sujet PYK2: PTK2B protein tyrosine kinase 2 beta, also known as PTK2B, PKB, PTK, CAKB, FAK2, FRNK. Entrez Protein NP_004094. It is a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
Synonyms: PKB, PTK, CAKB, FAK2, FRNK, PTK2B
Poids moléculaire 115.8kDa
ID gène 2185
Pathways EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling
Indications d'application Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Produit citée dans: "Fresh concepts in dental design." dans: Journal of the California Dental Association, Vol. 32, Issue 5, pp. 365-6, 2004 (PubMed).

Background publications van der Horst, Weber, Ullrich: "Tyrosine phosphorylation of PYK2 mediates heregulin-induced glioma invasion: novel heregulin/HER3-stimulated signaling pathway in glioma." dans: International journal of cancer. Journal international du cancer, Vol. 113, Issue 5, pp. 689-98, 2004 (PubMed).

Haglund, Ivankovic-Dikic, Shimokawa, Kruh, Dikic: "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites." dans: Journal of cell science, Vol. 117, Issue Pt 12, pp. 2557-68, 2004 (PubMed).

Dylla, Deyle, Theunissen, Padurean, Verfaillie: "Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products." dans: Experimental hematology, Vol. 32, Issue 4, pp. 365-74, 2004 (PubMed).

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