RAF1 anticorps (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1) (pSer259)

Details for Product anti-RAF1 Antibody No. ABIN966940, Fournisseur: Connectez-vous pour afficher
Antigène
  • CRAF
  • NS5
  • Raf-1
  • c-Raf
  • c-raf
  • craf
  • raf1
  • RAF1
  • 6430402F14Rik
  • AA990557
  • BB129353
  • Craf1
  • D830050J10Rik
  • v-Raf
  • raf
  • cRaf
  • Raf-1 proto-oncogene, serine/threonine kinase
  • Raf-1 proto-oncogene, serine/threonine kinase a
  • v-raf-leukemia viral oncogene 1
  • Raf-1 proto-oncogene, serine/threonine kinase S homeolog
  • RAF1
  • Raf1
  • raf1a
  • raf1
  • raf1.S
Épitope
pSer259
80
72
47
47
46
43
41
34
34
29
28
21
21
19
19
16
15
15
15
15
15
12
7
7
7
6
6
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
836
414
389
27
25
18
16
13
9
8
8
5
4
4
2
2
1
1
1
Hôte
Lapin
783
63
11
6
2
Conjugué
Cet anticorp RAF1 est non-conjugé
45
45
44
30
30
29
14
14
12
12
12
12
12
12
12
12
12
2
2
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC)
516
369
223
172
156
102
50
49
20
18
17
7
2
2
2
2
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène The antiserum was produced against synthesized phosphopeptide derived from human Raf-1 around the phosphorylation site of serine 259 (S-T-SP-T-P).
Specificité Raf-1 (phospho-Ser259) antibody detects endogenous levels of Raf-1 only when phosphorylated at serine 259.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Autre désignation Raf1 (RAF1 Antibody Extrait)
Pathways Signalisation MAPK, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Stem Cell Maintenance, Hepatitis C, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
Indications d'application WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Produit citée dans: Gabriel, Bravery, Dougherty, Kayley, Malster, Scales: "Vascular access: indications and implications for patient care." dans: Nursing standard (Royal College of Nursing (Great Britain) : 1987), Vol. 19, Issue 26, pp. 45-52, 2005 (PubMed).

Dougherty, Müller, Ritt, Zhou, Zhou, Copeland, Conrads, Veenstra, Lu, Morrison: "Regulation of Raf-1 by direct feedback phosphorylation." dans: Molecular cell, Vol. 17, Issue 2, pp. 215-24, 2005 (PubMed).

Hekman, Fischer, Wennogle, Wang, Campbell, Rapp: "Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation." dans: FEBS letters, Vol. 579, Issue 2, pp. 464-8, 2005 (PubMed).

Chong, Lee, Guan: "Positive and negative regulation of Raf kinase activity and function by phosphorylation." dans: The EMBO journal, Vol. 20, Issue 14, pp. 3716-27, 2001 (PubMed).

King, Sun, Diaz, Barnard, Miao, Bagrodia, Marshall: "The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338." dans: Nature, Vol. 396, Issue 6707, pp. 180-3, 1998 (PubMed).

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