Ret Proto-Oncogene anticorps (RET) (AA 896-1063)

Details for Product anti-RET Antibody No. ABIN966961, Fournisseur: Connectez-vous pour afficher
Antigène
  • c-ret
  • cret
  • etID315074.13
  • ret1
  • wu:fd13h01
  • X-ret
  • ret-A
  • xret
  • RET
  • MTC1
  • CDHF12
  • CDHR16
  • HSCR1
  • MEN2A
  • MEN2B
  • PTC
  • RET-ELE1
  • RET51
  • RET9
  • c-Ret
  • ret proto-oncogene receptor tyrosine kinase
  • ret proto-oncogene S homeolog
  • ret proto-oncogene
  • ret
  • ret.S
  • RET
  • Ret
Épitope
AA 896-1063
48
42
26
26
25
22
18
15
14
11
11
8
7
7
7
7
7
7
7
6
5
5
4
4
3
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivité
Humain
357
129
119
9
3
2
2
2
2
1
1
1
1
1
1
1
Hôte
Souris
257
101
2
2
1
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp Ret Proto-Oncogene est non-conjugé
15
14
14
11
9
9
6
6
6
6
6
5
5
5
5
5
5
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
267
151
121
65
65
37
34
13
7
6
6
3
3
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Purified recombinant fragment of RET (aa896-1063) expressed in E. Coli.
Clone 8D10C9
Isotype IgG1
Purification Ascitic fluid
Plasmids, Primers & others Plasmids, Primers & others Ret Proto-Oncogene products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation RET (RET Antibody Extrait)
Sujet RET (ret proto-oncogene) is a member of the cadherin superfamily and a receptor tyrosine kinase, which are cellsurface molecules that transduce signals for cell growth and differentiation. It can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung's disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.
Synonyms: RET
ID gène 5979
Pathways Signalisation RTK, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
Indications d'application Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Background publications Young, Anderson, Anderson: "Guidance cues involved in the development of the peripheral autonomic nervous system." dans: Autonomic neuroscience : basic & clinical, Vol. 112, Issue 1-2, pp. 1-14, 2004 (PubMed).

Myers, Mulligan: "The RET receptor is linked to stress response pathways." dans: Cancer research, Vol. 64, Issue 13, pp. 4453-63, 2004 (PubMed).

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