RICTOR anticorps (RPTOR Independent Companion of MTOR, Complex 2)

Details for Product anti-RICTOR Antibody No. ABIN966967, Fournisseur: Connectez-vous pour afficher
Antigène
  • PIA
  • mAVO3
  • 4921505C17Rik
  • 6030405M08Rik
  • AVO3
  • AW492497
  • D530039E11Rik
  • Fyb
  • RPTOR independent companion of MTOR complex 2
  • RPTOR independent companion of MTOR, complex 2
  • RICTOR
  • Rictor
Reactivité
Humain, Singe, Souris
191
102
20
15
14
12
4
3
2
2
2
1
1
Hôte
Souris
137
53
21
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp RICTOR est non-conjugé
7
7
6
5
5
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
157
104
87
51
29
28
24
21
13
6
2
2
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Purified recombinant fragment of human RICTOR expressed in E. Coli.
Clone 4H5
Isotype IgG1
Purification Ascitic fluid
Plasmids, Primers & others Plasmids, Primers & others RICTOR products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation RICTOR (RICTOR Antibody Extrait)
Sujet Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals . mTOR is a large protein kinase with two different complexes. One complex contains mTOR, µL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, µL, Sin1 and rictor. The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro . This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes. This complex has also been shown to phosphorylate the rapamycinresistant mutants of S6K1, another effector of mTOR .
Synonyms: PIA, mAVO3, KIAA1999, MGC39830, DKFZp686B11164, RICTOR
Poids moléculaire 192kDa
ID gène 253260
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events
Indications d'application Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Produit citée dans: Martin, Masri, Bernath, Nishimura, Gera: "Hsp70 associates with Rictor and is required for mTORC2 formation and activity." dans: Biochemical and biophysical research communications, Vol. 372, Issue 4, pp. 578-83, 2008 (PubMed).

Yang, Inoki, Ikenoue, Guan: "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity." dans: Genes & development, Vol. 20, Issue 20, pp. 2820-32, 2006 (PubMed).

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