ROR1 anticorps (Receptor Tyrosine Kinase-Like Orphan Receptor 1) (Extracellular)

Details for Product anti-ROR1 Antibody No. ABIN966973, Fournisseur: Connectez-vous pour afficher
Antigène
  • NTRKR1
  • dJ537F10.1
  • 2810404D04Rik
  • Ntrkr1
  • mRor1
  • RGD1559469
  • ROR1
  • fi34e02
  • si:dkey-209n16.1
  • wu:fi34e02
  • receptor tyrosine kinase like orphan receptor 1
  • receptor tyrosine kinase-like orphan receptor 1
  • ROR1
  • Ror1
  • ror1
Épitope
Extracellular, AA 30-406
18
18
14
12
7
7
7
6
5
5
4
3
3
2
2
2
1
1
1
1
1
Reactivité
Humain
127
55
45
5
3
3
3
3
2
2
1
1
1
1
1
Hôte
Souris
120
32
16
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp ROR1 est non-conjugé
10
10
7
7
6
4
4
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Immunofluorescence (IF), ELISA, Western Blotting (WB)
132
67
40
34
15
9
9
5
4
4
3
2
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells
Clone 2H6
Isotype IgG1
Purification Ascitic fluid
Plasmids, Primers & others Plasmids, Primers & others ROR1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation ROR1 (ROR1 Antibody Extrait)
Sujet ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases.
Synonyms: ROR1
Poids moléculaire 101kDa
ID gène 4919
Pathways Signalisation RTK, Signalisation WNT, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
Indications d'application Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Background publications Paganoni, Ferreira: "Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2." dans: Journal of cell science, Vol. 118, Issue Pt 2, pp. 433-46, 2005 (PubMed).

Reddy, Phatak, Pleasure: "Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains." dans: Oncogene, Vol. 13, Issue 7, pp. 1555-9, 1996 (PubMed).

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