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Sonic Hedgehog anticorps

SHH Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal 8G3 unconjugated
N° du produit ABIN967021
  • Antigène Voir toutes Sonic Hedgehog (SHH) Anticorps
    Sonic Hedgehog (SHH)
    Reactivité
    • 62
    • 54
    • 40
    • 17
    • 9
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 74
    • 10
    • 8
    • 1
    • 1
    Souris
    Clonalité
    • 66
    • 28
    Monoclonal
    Conjugué
    • 54
    • 10
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Sonic Hedgehog est non-conjugé
    Application
    • 74
    • 32
    • 25
    • 14
    • 13
    • 11
    • 11
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 1
    Western Blotting (WB), ELISA
    Purification
    Ascitic fluid
    Immunogène
    Purified recombinant fragment of human SHH expressed in E. Coli.
    Clone
    8G3
    Isotype
    IgG1
    Top Product
    Discover our top product SHH Anticorps primaire
  • Indications d'application
    Western Bloting: 1/500 - 1/2000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
  • Lee, Lee, Jung, Park, Park, Hahm: "Late reactivation of sonic hedgehog by Helicobacter pylori results in population of gastric epithelial cells that are resistant to apoptosis: implication for gastric carcinogenesis." dans: Cancer letters, Vol. 287, Issue 1, pp. 44-53, (2010) (PubMed).

    Dierker, Dreier, Migone, Hamer, Grobe: "Heparan sulfate and transglutaminase activity are required for the formation of covalently cross-linked hedgehog oligomers." dans: The Journal of biological chemistry, Vol. 284, Issue 47, pp. 32562-71, (2009) (PubMed).

  • Antigène
    Sonic Hedgehog (SHH)
    Autre désignation
    SHH (SHH Produits)
    Synonymes
    anticorps HHG1, anticorps HLP3, anticorps HPE3, anticorps MCOPCB5, anticorps SMMCI, anticorps TPT, anticorps TPTPS, anticorps 9530036O11Rik, anticorps Dsh, anticorps Hhg1, anticorps Hx, anticorps Hxl3, anticorps M100081, anticorps fc83d08, anticorps shh, anticorps syu, anticorps vhh-1, anticorps vhh1, anticorps wu:fc83d08, anticorps Xhh, anticorps hedgehog, anticorps xshh, anticorps SHH, anticorps twh, anticorps twhh, anticorps sonic hedgehog, anticorps sonic hedgehog a, anticorps sonic hedgehog L homeolog, anticorps sonic hedgehog protein A, anticorps sonic hedgehog b, anticorps SHH, anticorps Shh, anticorps shha, anticorps shh.L, anticorps shh, anticorps shhb
    Sujet
    This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.
    Synonyms: TPT, HHG1, HLP3, HPE3, SMMCI, TPTPS, MCOPCB5, SHH
    Poids moléculaire
    49.6kDa
    ID gène
    6469
    Pathways
    Signalisation Hedgehog, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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