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SHPRH anticorps (N-Term)

SHPRH Reactivité: Humain IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN967027
  • Antigène Voir toutes SHPRH Anticorps
    SHPRH (SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase (SHPRH))
    Épitope
    • 15
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 28
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 25
    • 4
    Lapin
    Clonalité
    • 26
    • 3
    Polyclonal
    Conjugué
    • 11
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SHPRH est non-conjugé
    Application
    • 23
    • 13
    • 13
    • 10
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC)
    Immunogène
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human SHPRH (E3 ubiquitin-protein ligase SHPRH )
    Top Product
    Discover our top product SHPRH Anticorps primaire
  • Restrictions
    For Research Use only
  • Stock
    4 °C
  • Motegi, Liaw, Lee, Roest, Maas, Wu, Moinova, Markowitz, Ding, Hoeijmakers, Myung: "Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 34, pp. 12411-6, (2008) (PubMed).

    Motegi, Sood, Moinova, Markowitz, Liu, Myung: "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination." dans: The Journal of cell biology, Vol. 175, Issue 5, pp. 703-8, (2006) (PubMed).

    Sood, Makalowska, Galdzicki, Hu, Eddings, Robbins, Moses, Namkoong, Chen, Trent: "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region." dans: Genomics, Vol. 82, Issue 2, pp. 153-61, (2003) (PubMed).

  • Antigène
    SHPRH (SNF2 Histone Linker PHD RING Helicase, E3 Ubiquitin Protein Ligase (SHPRH))
    Autre désignation
    SHPRH (SHPRH Produits)
    Synonymes
    anticorps bA545I5.2, anticorps 2610103K11Rik, anticorps AA450458, anticorps AU024614, anticorps BC006883, anticorps D230017O13Rik, anticorps E130018M05, anticorps SNF2 histone linker PHD RING helicase, anticorps SHPRH, anticorps Shprh
    Sujet
    SHPRH (E3 ubiquitin-protein ligase SHPRH ) involved in DNA repair. Upon genotoxic stress, SHPRH accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of noncanonical poly-ubiquitin chains linked through 'Lys-63'. SHPRH interacts with HLTF, PCNA, UBE2N and RAD18. The RING finger mediates E3 ubiquitin ligase activity. SHPRH belongs to the SNF2/RAD54 helicase family. SHPRH contains 1 helicase ATP-binding domain, 1 helicase C-terminal domain, 1 histone H1 domain, 1 PHD-type zinc finger and 1 RING-type zinc finger.
    Synonyms: KIAA2023, SNF2, histone-linker, PHD and RING finger domain-containing helicase.
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