SMAD4 anticorps

N° du produit ABIN967047

Détail du produit anti-SMAD4 anticorps

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SMAD4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human SMAD4 expressed in E. Coli.

Clone: 4G1C6

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-SMAD4 (ABIN967047)

Yao, Yin, Lian, Tian, Liu, Li, Sun: "MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4." dans: Molecular endocrinology (Baltimore, Md.), Vol. 24, Issue 3, pp. 540-51, (2010) (PubMed).

Smolander, Vogt, Maillard, Zweiacker, Littke, Hengelage, Burnier: "Dose-dependent acute and sustained renal effects of the endothelin receptor antagonist avosentan in healthy subjects." dans: Clinical pharmacology and therapeutics, Vol. 85, Issue 6, pp. 628-34, (2009) (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." dans: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Détails sur SMAD4

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Autre désignation: SMAD4 (SMAD4 Produits)

Synonymes: anticorps smad4, anticorps DPC4, anticorps JIP, anticorps MADH4, anticorps MYHRS, anticorps AW743858, anticorps D18Wsu70e, anticorps Madh4, anticorps XSmad4alpha, anticorps Xsmad4, anticorps dpc4, anticorps jip, anticorps madh4, anticorps xsmad4a, anticorps SMAD family member 4, anticorps Smad4 protein, anticorps SMAD family member 4, gene 1 L homeolog, anticorps SMAD4, anticorps smad4, anticorps Smad4, anticorps smad4.1.L

Sujet: Common mediator of signal transduction by TGF-beta (transforming growth factor) superfamily, SMAD4 is the common SMAD (co-SMAD). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. May act as a tumor suppressor mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Synonyms: JIP, DPC4, MADH4, SMAD4

Poids moléculaire: 65kDa

ID gène: 4089

Pathways: Cycle Cellulaire, Chromatin Binding, Autophagy