SLC39A4 anticorps (C-Term)

N° du produit ABIN967274

Détail du produit anti-SLC39A4 anticorps

Antigène: SLC39A4 (Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC39A4 est non-conjugé

Application: Immunohistochemistry (IHC)

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ZIP4 (Zinc transporter ZIP4)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-SLC39A4 (ABIN967274)

Kim, Wang, Dufner-Beattie, Andrews, Eide, Petris: "Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane." dans: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4523-30, (2004) (PubMed).

Küry, Dréno, Bézieau, Giraudet, Kharfi, Kamoun, Moisan: "Identification of SLC39A4, a gene involved in acrodermatitis enteropathica." dans: Nature genetics, Vol. 31, Issue 3, pp. 239-40, (2002) (PubMed).

Wang, Zhou, Kuo, Zemansky, Gitschier: "A novel member of a zinc transporter family is defective in acrodermatitis enteropathica." dans: American journal of human genetics, Vol. 71, Issue 1, pp. 66-73, (2002) (PubMed).

Détails sur SLC39A4

Antigène: SLC39A4 (Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4))

Autre désignation: ZIP4 (SLC39A4 Produits)

Synonymes: anticorps AEZ, anticorps AWMS2, anticorps ZIP4, anticorps 1600025H15Rik, anticorps AU041686, anticorps solute carrier family 39 member 4, anticorps solute carrier family 39 (zinc transporter), member 4, anticorps SLC39A4, anticorps slc39a4, anticorps Slc39a4

Sujet: ZIP4 (Zinc transporter ZIP4) plays an important role in cellular zinc homeostasis as a zinc transporter. ZIP4 is regulated in response to zinc availability. ZIP4 is a multi-pass membrane protein and is colocalized with TFRC in the recycling endosomes. ZIP4 cycles between endosomal compartments and the plasma membrane in response to zinc availability. ZIP4 is highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ). AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinicals features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal. ZIP4 belongs to the ZIP transporter (TC 2.A.5) family.
Synonyms: SLC39A4 (Solute carrier family 39 member 4), ZIP-4 (Zrt- and Irt-like protein 4)

Pathways: Transition Metal Ion Homeostasis, Autophagy