NFAT1 anticorps (AA 433-567)

N° du produit ABIN967558

Détail du produit anti-NFAT1 anticorps

Antigène: NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1))

Épitope: AA 433-567

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NFAT1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Marque: BD Pharmingen™

Réactivité croisée: Souris

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human NF-ATc2 aa. 433-567 Peptide

Clone: 4G6-G5

Isotype: IgG2a kappa

Information d'application

Commentaires:

Related Products: ABIN968537, ABIN967389, ABIN968123

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-NFAT1 (ABIN967558)

Xanthoudakis, Viola, Shaw, Luo, Wallace, Bozza, Luk, Curran, Rao: "An enhanced immune response in mice lacking the transcription factor NFAT1." dans: Science (New York, N.Y.), Vol. 272, Issue 5263, pp. 892-5, (1996) (PubMed).

Crabtree: "Contingent genetic regulatory events in T lymphocyte activation." dans: Science (New York, N.Y.), Vol. 243, Issue 4889, pp. 355-61, (1989) (PubMed).

Détails sur NFAT1

Antigène: NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1))

Autre désignation: NF-ATc2 (NFAT1 Produits)

Synonymes: anticorps NFATC2, anticorps AI607462, anticorps NF-ATc2, anticorps NFAT1, anticorps NFAT1-D, anticorps Nfatp, anticorps NFATP, anticorps nuclear factor of activated T-cells 2, anticorps nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2, anticorps NFATC2, anticorps nfatc2, anticorps Nfatc2

Sujet: The NF-AT family of transcription factors are regulators of early immune response genes in T cells following their activation by CD40L, FasL and interleukins including IL-2, -3, -4 and -5. NF-AT proteins function in both signal transduction and transcription control. The DNA binding, active NF-AT complex contains a cytoplasmic, Ca2+/calcineurin dependent, cyclosporin sensitive subunit, designated NF-ATc, which is present in the cytoplasm of resting cells. Upon cell activation, NF-ATc is dephosphorylated and thus activated by calcineurin, resulting in rapid translocation of NF-ATc to the nucleus. The active NF-AT complex also contains a nuclear component, designated NF-ATn. In vitro, NF-AT cooperates with the mitogenic transcription factor AP-1 to induce multiple cytokine genes. NF-ATc is encoded by four genes: NF-ATc1 (originally named NF-ATc), NF-ATc2 (originally named NF-ATp), NF-ATc3 (NF-AT3), and NF-ATc4 (NF-AT4). These proteins are differentially expressed in tissues, suggesting that each may activate distinct sets of genes. NF-ATc2 is constutively expressed in resting immune cells. NF-ATc2 is required for the development of Th2 responses and plays a role in the production of IL-4.
Synonyms: NFAT1, NFATP, KIAA0611

Poids moléculaire: 97-135 kDa

Pathways: Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, VEGF Signaling, BCR Signaling