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SOS1 anticorps (AA 1-109)

SOS1 Reactivité: Humain, Souris, Rat, Chien WB, IF, IP, IHC Hôte: Souris Monoclonal 25-SOS1 unconjugated
N° du produit ABIN967741
  • Antigène Voir toutes SOS1 Anticorps
    SOS1 (Son of Sevenless Homolog 1 (SOS1))
    Épitope
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-109
    Reactivité
    • 26
    • 11
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Chien
    Hôte
    • 18
    • 10
    • 1
    Souris
    Clonalité
    • 19
    • 10
    Monoclonal
    Conjugué
    • 26
    • 1
    • 1
    • 1
    Cet anticorp SOS1 est non-conjugé
    Application
    • 21
    • 14
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC)
     Réactivité croisée
    Rat (Rattus), Chien, Humain
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse mSos1 aa. 1-109
    Clone
    25-SOS1
    Isotype
    IgG1
    Top Product
    Discover our top product SOS1 Anticorps primaire
  • Commentaires

    Related Products: ABIN968539, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20° C.
  • Furuta, Miura, Copeland, Shang, Oshima, Kamata: "Light Chain 3 associates with a Sos1 guanine nucleotide exchange factor: its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling." dans: Oncogene, Vol. 21, Issue 46, pp. 7060-6, (2002) (PubMed).

    Kardinal, Konkol, Lin, Eulitz, Schmidt, Estrov, Talpaz, Arlinghaus, Feller: "Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes." dans: Blood, Vol. 98, Issue 6, pp. 1773-81, (2001) (PubMed).

    Salojin, Zhang, Meagher, Delovitch: "ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells." dans: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5966-75, (2000) (PubMed).

    Buday, Downward: "Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor." dans: Cell, Vol. 73, Issue 3, pp. 611-20, (1993) (PubMed).

    Egan, Giddings, Brooks, Buday, Sizeland, Weinberg: "Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation." dans: Nature, Vol. 363, Issue 6424, pp. 45-51, (1993) (PubMed).

  • Antigène
    SOS1 (Son of Sevenless Homolog 1 (SOS1))
    Autre désignation
    Sos1 (SOS1 Produits)
    Synonymes
    anticorps GF1, anticorps GGF1, anticorps GINGF, anticorps HGF, anticorps NS4, anticorps 4430401P03Rik, anticorps 9630010N06, anticorps AI449023, anticorps SOS Ras/Rac guanine nucleotide exchange factor 1, anticorps son of sevenless homolog 1 (Drosophila), anticorps SOS1, anticorps Sos1
    Classe de substances
    Viral Protein
    Sujet
    The Sos (son of sevenless) gene was originally identified in Drosophila, and two mammalian homologues (mSos1 and mSos2) were isolated from a mouse cDNA library. These two cDNAs predict proteins that are approximately 70% identical in their amino acid residues. Both mSos1 and mSos2 are expressed in a wide number of mouse embryonic and adult tissues as well as in several cell lines. The human homologues, hSos1 and hSos2 have also been isolated and show a very high degree of amino acid identity to the mouse genes (98% for Sos1). Sos1 has a predicted molecular weight of 150kDa, but the apparent molecular weight is closer to 170 kDa, presumably due to a high proline content. The mammalian Sos1 protein has a highly specific guanine nucleotide exchange activity toward p21ras . In EGF-stimulated cells, Sos1 interacts with the SH3 domains of GRB2, and GRB2 binds via its SH2 domain to tyrosine 1068 of the activated EGF receptor. Thus, GRB2 recruits Sos1 to the plasma membrane and enables it to activate the Ras signaling pathway by enhancing GTP loading on p21ras .
    Poids moléculaire
    170 kDa
    Pathways
    Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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