Caveolin-1 anticorps (AA 1-178)

N° du produit ABIN967950

Détail du produit anti-Caveolin-1 anticorps

Antigène: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Épitope: AA 1-178

Reactivité: Humain, Rat, Souris, Chien, Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Caveolin-1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: RSV-CEF Caveolin aa. 1-178

Clone: 2297-Caveolin 1

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN968536, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-Caveolin-1 (ABIN967950)

Woodman, Park, Cohen, Cheung, Chandra, Shirani, Tang, Jelicks, Kitsis, Christ, Factor, Tanowitz, Lisanti: "Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade." dans: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38988-97, (2002) (PubMed).

Ushio-Fukai, Hilenski, Santanam, Becker, Ma, Griendling, Alexander: "Cholesterol depletion inhibits epidermal growth factor receptor transactivation by angiotensin II in vascular smooth muscle cells: role of cholesterol-rich microdomains and focal adhesions in angiotensin II signaling." dans: The Journal of biological chemistry, Vol. 276, Issue 51, pp. 48269-75, (2001) (PubMed).

Galbiati, Volonte, Brown, Weinstein, Ben-Zeev, Pestell, Lisanti: "Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains." dans: The Journal of biological chemistry, Vol. 275, Issue 30, pp. 23368-77, (2000) (PubMed).

Breton, Lisanti, Tyszkowski, McLaughlin, Brown: "Basolateral distribution of caveolin-1 in the kidney. Absence from H+-atpase-coated endocytic vesicles in intercalated cells." dans: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 46, Issue 2, pp. 205-14, (1998) (PubMed).

Conrad, Smart, Ying, Anderson, Bloom: "Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps." dans: The Journal of cell biology, Vol. 131, Issue 6 Pt 1, pp. 1421-33, (1996) (PubMed).

Détails sur Caveolin-1

Antigène: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Autre désignation: Caveolin 1 (CAV1 Produits)

Synonymes: anticorps fc07c04, anticorps wu:fc07c04, anticorps Cav-1, anticorps bscl3, anticorps cav1, anticorps cav1a, anticorps cgl3, anticorps vip21, anticorps cav1b, anticorps caveolin-1, anticorps cav, anticorps mstp085, anticorps Caveolin-1, anticorps CAV1, anticorps cav-1, anticorps Cav, anticorps caveolin 1, anticorps BSCL3, anticorps CGL3, anticorps MSTP085, anticorps PPH3, anticorps VIP21, anticorps caveolin 1, anticorps caveolin 1 L homeolog, anticorps caveolin 1 S homeolog, anticorps caveolin 1, caveolae protein, anticorps caveolin 1, caveolae protein, 22kDa, anticorps Caveolin, anticorps cav1, anticorps cav1.L, anticorps cav1.S, anticorps CAV1, anticorps Cav1, anticorps cav-1

Sujet: Identified as a tyrosine phosphorylated protein in Rous sarcoma virus-transformed chick embryo fibroblasts (CEF), caveolin is now known to be ubiquitously expressed. Caveolin (also known as VIP21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. This transmembrane protein plays a structural role in these specializations. Caveolin is also present at the trans-Golgi network (TGN) and similar quantities are found in apically and basolaterally destined transport vesicles. Caveolin is part of a complex containing glycosylphosphatidylinositol (GPI)-linked molecules and cytoplasmic signaling proteins. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmic signaling molecules, such as c-yes, Annexin II, and hetero-trimeric G proteins. Caveolin-1 can generate two forms, alpha and beta, due to alternate splicing of the mRNA. The alpha isoform has been reported to be observed at 24 kD and the beta isoform at 21 kD. Caveolin-1 forms large lipid-binding homo-oligomers which are believed to play a role in caveolae formation. It may also function as a scaffolding protein which concentrates andorganizes signaling molecules, a role supported by the fact that caveolin-1 interacts directly with inactive Ras and G-protein alpha subunits. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 21-24 kDa

Pathways: Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals