NFAT1 anticorps (AA 29-181)
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- Antigène Voir toutes NFAT1 Anticorps
- NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1))
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Épitope
- AA 29-181
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Reactivité
- Humain, Chien
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp NFAT1 est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
- Réactivité croisée
- Chien
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human NFAT-1 aa. 29-181
- Clone
- 1-NFAT
- Isotype
- IgG1
- Top Product
- Discover our top product NFAT1 Anticorps primaire
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- Commentaires
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Related Products: ABIN967389, ABIN968537, ABIN968619
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20°C.
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cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression." dans: Blood, Vol. 101, Issue 3, pp. 998-1006, (2003) (PubMed).
: "Reduced NFAT1 protein expression in human umbilical cord blood T lymphocytes." dans: Blood, Vol. 94, Issue 9, pp. 3101-7, (1999) (PubMed).
: "Constitutive dephosphorylation and activation of a member of the nuclear factor of activated T cells, NF-AT1, in Tax-expressing and type I human T-cell leukemia virus-infected human T cells." dans: The Journal of biological chemistry, Vol. 272, Issue 3, pp. 1425-8, (1997) (PubMed).
: "The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB." dans: Molecular and cellular biology, Vol. 13, Issue 3, pp. 1911-9, (1993) (PubMed).
: "Isolation of the cyclosporin-sensitive T cell transcription factor NFATp." dans: Science (New York, N.Y.), Vol. 262, Issue 5134, pp. 750-4, (1993) (PubMed).
: "
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cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression." dans: Blood, Vol. 101, Issue 3, pp. 998-1006, (2003) (PubMed).
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- Antigène
- NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 (NFAT1))
- Autre désignation
- NFAT-1 (NFAT1 Produits)
- Synonymes
- anticorps NFATC2, anticorps AI607462, anticorps NF-ATc2, anticorps NFAT1, anticorps NFAT1-D, anticorps Nfatp, anticorps NFATP, anticorps nuclear factor of activated T-cells 2, anticorps nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2, anticorps NFATC2, anticorps nfatc2, anticorps Nfatc2
- Sujet
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T cells are activated and induced to proliferate following binding of their respective antigen. The process of includes expression of genes that encode factors (i.e., cytokines) which regulate various cell types. Modulation of gene expression is conducted by an array of specific interactions between transcription factors and DNA. NFAT-1 (Nuclear Factor of Activated T cells) is a transcription factor that regulates expression of the interleukin-2 gene. Thus, NFAT-1 DNA binding activity is undetectable in resting cells, but increases during T-cell activation. NFAT-1, a protein of 921 amino acids, is part of an oligomeric transcription factor that also contains Fra-1 and JunB. NFAT-1 was initially described as a phosphoprotein and is dephosphorylated in activated T cells transformed with the leukemia virus HTLV-l.
Synonyms: NF-ATc2, NFATP, KIAA0611 - Poids moléculaire
- 97-135 kDa
- Pathways
- Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, VEGF Signaling, BCR Signaling
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