TEAD1 anticorps (AA 86-199)

N° du produit ABIN968251

Détail du produit anti-TEAD1 anticorps

Antigène: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Épitope: AA 86-199

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TEAD1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Souris

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human TEF-1 aa. 86-199

Clone: 31-TEF

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-TEAD1 (ABIN968251)

Ueyama, Zhu, Valenzuela, Suzow, Stewart: "Identification of the functional domain in the transcription factor RTEF-1 that mediates alpha 1-adrenergic signaling in hypertrophied cardiac myocytes." dans: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17476-80, (2000) (PubMed).

Deshpande, Chopra, Rangarajan, Shashidhara, Rodrigues, Krishna: "The human transcription enhancer factor-1, TEF-1, can substitute for Drosophila scalloped during wingblade development." dans: The Journal of biological chemistry, Vol. 272, Issue 16, pp. 10664-8, (1997) (PubMed).

Gupta, Amin, Gupta, Hay, Zak: "Transcription enhancer factor 1 interacts with a basic helix-loop-helix zipper protein, Max, for positive regulation of cardiac alpha-myosin heavy-chain gene expression." dans: Molecular and cellular biology, Vol. 17, Issue 7, pp. 3924-36, (1997) (PubMed).

Jacquemin, Hwang, Martial, Dollé, Davidson: "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain." dans: The Journal of biological chemistry, Vol. 271, Issue 36, pp. 21775-85, (1996) (PubMed).

Xiao, Davidson, Matthes, Garnier, Chambon: "Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1." dans: Cell, Vol. 65, Issue 4, pp. 551-68, (1991) (PubMed).

Détails sur TEAD1

Antigène: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Autre désignation: TEF-1 (TEAD1 Produits)

Synonymes: anticorps tead1, anticorps zgc:63696, anticorps TEAD1, anticorps xtead1, anticorps 2610024B07Rik, anticorps B230114H05Rik, anticorps Gtrgeo5, anticorps TEAD-1, anticorps TEF-1, anticorps Tcf13, anticorps mTEF-1, anticorps AA, anticorps NTEF-1, anticorps REF1, anticorps TCF-13, anticorps TCF13, anticorps XNTEF-1, anticorps xlNTEF-1, anticorps TEA domain family member 1a, anticorps TEA domain transcription factor 1, anticorps TEA domain family member 1 (SV40 transcriptional enhancer factor), anticorps TEA domain family member 1, anticorps TEA domain family member 1 (SV40 transcriptional enhancer factor) S homeolog, anticorps TEA domain family member 1b, anticorps tead1a, anticorps TEAD1, anticorps tead1, anticorps Tead1, anticorps tead1.S, anticorps tead1b

Sujet: TEF-1 (transcription enhancer factor-1) is a member of a family of transcription factors that contain an evolutionarily conserved DNA binding domain (DBD), TEA/ATTS. TEF-1 was identified as a HeLa cell transcriptional activator that bound, via its TEA domain, to the GT-IIC and Sph enhancer elements. Comparison of various enhancers indicates that TEF-1 binds to highly degenerate DNA sequences and cooperatively interacts with tandem repeats of its binding sites, which increases its enhancer activity. However, the DNA binding activities of TEF-1 are modulated by sequences outside the DBD. The N-terminal basic portion of TEF-1 contains the DBD. The C-terminal portion contains the transactivation domain and a zinc finger-like motif that is thought to be involved in protein dimerization or interaction with additional transcription factors. TEF-1 induced transcription requires a limiting transcriptional intermediary factor (TIF) and a TATA-binding protein associated factor (hTAFIIs). Although TEF-1 is expressed ubiquitously during embryogenesis, its expression is limited to adult kidney, heart, brain, skeletal muscle, and lungs. Disruption of murine TEF-1 gene results in fetal death.

Poids moléculaire: 53 kDa

Pathways: Regulation of Lipid Metabolism by PPARalpha