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APBA3 anticorps (AA 63-185)

APBA3 Reactivité: Humain, Souris WB, IF, BI Hôte: Souris Monoclonal 32-Mint3 unconjugated
N° du produit ABIN968505
  • Antigène Voir toutes APBA3 Anticorps
    APBA3 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 3 (APBA3))
    Épitope
    • 15
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 63-185
    Reactivité
    • 19
    • 17
    • 2
    • 1
    Humain, Souris
    Hôte
    • 34
    • 1
    Souris
    Clonalité
    • 35
    Monoclonal
    Conjugué
    • 16
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp APBA3 est non-conjugé
    Application
    • 33
    • 16
    • 13
    • 13
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI)
     Réactivité croisée
    Humain
    Attributs du produit
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogène
    Mouse Mint3 aa. 63-185
    Clone
    32-Mint3
    Isotype
    IgG1
  • Commentaires

    Related Products: ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store undiluted at -20°C.
  • McLoughlin, Irving, Brownlees, Brion, Leroy, Miller: "Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease." dans: The European journal of neuroscience, Vol. 11, Issue 6, pp. 1988-94, (1999) (PubMed).

    Borg, Straight, Kaech, de Taddéo-Borg, Kroon, Karnak, Turner, Kim, Margolis: "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting." dans: The Journal of biological chemistry, Vol. 273, Issue 48, pp. 31633-6, (1998) (PubMed).

    Borg, Yang, De Taddéo-Borg, Margolis, Turner: "The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion." dans: The Journal of biological chemistry, Vol. 273, Issue 24, pp. 14761-6, (1998) (PubMed).

  • Antigène
    APBA3 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 3 (APBA3))
    Autre désignation
    Mint3 (APBA3 Produits)
    Synonymes
    anticorps AW208791, anticorps Mint-3, anticorps X11gamma, anticorps lin-10, anticorps mint3, anticorps MGC:15815, anticorps X11L2, anticorps Mint3, anticorps amyloid beta precursor protein binding family A member 3, anticorps amyloid beta (A4) precursor protein-binding, family A, member 3, anticorps APBA3, anticorps Apba3
    Sujet
    Munc18-1-interacting proteins, Mint1, Mint2, and Mint3, are members of the X11 family of proteins, which contain a phosphotyrosine-binding (PTB) domain and two PSD-95-DLG-ZO-1 (PDZ) domains. The PTB domain binds Asn-Pro-X-pTyr, a beta-turn motif found on activated growth factor receptors and other signaling molecules. PDZ domains bind the C-terminus of proteins involved in receptor and channel clustering and protein localization in polarized cells. Both Mint1 and Mint2 are expressed primarily in the nervous system and may interact with Munc18-1 and syntaxin to form a multimeric complex that mediates appropriate docking/fusion of synaptic vesicles. In addition, both Mint1 and Mint2 may be involved in Alzheimer's disease, since Mint2 colocalizes with amyloid precursor protein (APP) and is found in neuritic plaques, while Mint1 can bind APP, and inhibits the processing of APP to the amyloid beta peptide. Mint3 can also bind APP, but differs from Mint1 and Mint2 in its N-terminal region. It is also more widely expressed. Thus, Mint3 may function in signaling pathways, vesicle exocytosis, and/or protein targeting in a wide range of tissues. Mint3 has a calculated molecular weight of 61 kD, but reportedly is observed migrating at 86-89 kD. This antibody is routinely tested by western blot analysis.
    Synonyms: X11gamma
    Poids moléculaire
    86-89 kDa
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