ITGA5 anticorps
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- Antigène Voir toutes ITGA5 Anticorps
- ITGA5 (Integrin, alpha 5 (ITGA5))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ITGA5 est non-conjugé
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Application
- Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)
- Purification
- purified
- Immunogène
- Purified recombinant fragment of human ITGA5 expressed in E. coli.
- Clone
- 10F6
- Isotype
- IgG2a
- Top Product
- Discover our top product ITGA5 Anticorps primaire
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- Indications d'application
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
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Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain." dans: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19800-5, (2002) (PubMed).
: "Integrin activation by regulated dimerization and oligomerization of platelet endothelial cell adhesion molecule (PECAM)-1 from within the cell." dans: The Journal of cell biology, Vol. 152, Issue 1, pp. 65-73, (2001) (PubMed).
: "PECAM-1/CD31 trans-homophilic binding at the intercellular junctions is independent of its cytoplasmic domain; evidence for heterophilic interaction with integrin alphavbeta3 in Cis." dans: Molecular biology of the cell, Vol. 11, Issue 9, pp. 3109-21, (2000) (PubMed).
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Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain." dans: The Journal of biological chemistry, Vol. 277, Issue 22, pp. 19800-5, (2002) (PubMed).
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- Antigène
- ITGA5 (Integrin, alpha 5 (ITGA5))
- Autre désignation
- ITGA5 (ITGA5 Produits)
- Synonymes
- anticorps ITGA5, anticorps Cd49e, anticorps Fnra, anticorps VLA5, anticorps CD49e, anticorps FNRA, anticorps VLA5A, anticorps Itga5_retired, anticorps integrin subunit alpha 5, anticorps integrin alpha 5 (fibronectin receptor alpha), anticorps ITGA5, anticorps Itga5
- Sujet
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Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.
Aliases: FNRA, CD49e, VLA5A, ITGA5
- Poids moléculaire
- 114 kDa
- ID gène
- 3678
- HGNC
- 3678
- Pathways
- Integrin Complex
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