CD73 anticorps

N° du produit ABIN969322

Détail du produit anti-CD73 anticorps

Antigène: CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD73 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Purification: purified

Immunogène: Purified recombinant fragment of NT5E expressed in E. coli.

Clone: 1D7

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-CD73 (ABIN969322)

Zhou, Zhi, Zhou, Chen, Zhao, Shao, Ou, Yin: "Effects of ecto-5'-nucleotidase on human breast cancer cell growth in vitro and in vivo." dans: Oncology reports, Vol. 17, Issue 6, pp. 1341-6, (2007) (PubMed).

Wink, Braganhol, Tamajusuku, Casali, Karl, Barreto-Chaves, Sarkis, Battastini: "Extracellular adenine nucleotides metabolism in astrocyte cultures from different brain regions." dans: Neurochemistry international, Vol. 43, Issue 7, pp. 621-8, (2003) (PubMed).

Détails sur CD73

Antigène: CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))

Autre désignation: NT5E (NT5E Produits)

Synonymes: anticorps CALJA, anticorps CD73, anticorps E5NT, anticorps NT, anticorps NT5, anticorps NTE, anticorps eN, anticorps eNT, anticorps zgc:63784, anticorps NT5E, anticorps MGC114869, anticorps PSPTO2277, anticorps 2210401F01Rik, anticorps AI447961, anticorps Nt5, anticorps 5'-nucleotidase ecto, anticorps 5'-nucleotidase, ecto (CD73), anticorps 5'-nucleotidase, anticorps 5' nucleotidase, ecto, anticorps NT5E, anticorps nt5e, anticorps nt5e.S, anticorps PSPTO_2277, anticorps CBU_1233, anticorps MCA1322, anticorps Nt5e

Sujet:

Description: 5'-nucleotidase, ecto (NT5E), also known as CD73 (Cluster of Differentiation 73). Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase, EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.

Aliases: eN, NT5, CD73

Poids moléculaire: 70 kDa

ID gène: 4907

HGNC: 4907

Pathways: Synaptic Membrane, Ribonucleoside Biosynthetic Process