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RICTOR anticorps

RICTOR Reactivité: Humain, Souris, Singe WB, ELISA Hôte: Souris Monoclonal 4H5 unconjugated
N° du produit ABIN969383
  • Antigène Voir toutes RICTOR Anticorps
    RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))
    Reactivité
    • 65
    • 33
    • 3
    • 2
    • 1
    Humain, Souris, Singe
    Hôte
    • 59
    • 6
    • 1
    Souris
    Clonalité
    • 59
    • 7
    Monoclonal
    Conjugué
    • 39
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RICTOR est non-conjugé
    Application
    • 51
    • 38
    • 27
    • 11
    • 8
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human RICTOR expressed in E. coli.
    Clone
    4H5
    Isotype
    IgG1
    Top Product
    Discover our top product RICTOR Anticorps primaire
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Yang, Inoki, Ikenoue, Guan: "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity." dans: Genes & development, Vol. 20, Issue 20, pp. 2820-32, (2006) (PubMed).

  • Antigène
    RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))
    Autre désignation
    RICTOR (RICTOR Produits)
    Synonymes
    anticorps PIA, anticorps mAVO3, anticorps 4921505C17Rik, anticorps 6030405M08Rik, anticorps AVO3, anticorps AW492497, anticorps D530039E11Rik, anticorps Fyb, anticorps RPTOR independent companion of MTOR complex 2, anticorps RPTOR independent companion of MTOR, complex 2, anticorps RICTOR, anticorps Rictor
    Sujet

    Description: Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals . mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, Sin1 and rictor . The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro . This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes . This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR .

    Aliases: PIA, mAVO3, KIAA1999, MGC39830, DKFZp686B11164, RICTOR

    Poids moléculaire
    192 kDa
    ID gène
    253260
    HGNC
    253260
    Pathways
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events
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