SNAIL anticorps

N° du produit ABIN969409

Détail du produit anti-SNAIL anticorps

Antigène: SNAIL (SNAI1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SNAIL est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogène: Purified recombinant fragment of human SNAI1 expressed in E. coli.

Clone: 6D2

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-SNAIL (ABIN969409)

Wanami, Chen, Peiró, García de Herreros, Bachelder: "Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression." dans: Experimental cell research, Vol. 314, Issue 13, pp. 2448-53, (2008) (PubMed).

Herranz, Pasini, Díaz, Francí, Gutierrez, Dave, Escrivà, Hernandez-Muñoz, Di Croce, Helin, García de Herreros, Peiró: "Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor." dans: Molecular and cellular biology, Vol. 28, Issue 15, pp. 4772-81, (2008) (PubMed).

Détails sur SNAIL

Antigène: SNAIL (SNAI1)

Autre désignation: SNAI1 (SNAI1 Produits)

Synonymes: anticorps SLUGH2, anticorps SNA, anticorps SNAH, anticorps SNAIL, anticorps SNAIL1, anticorps dJ710H13.1, anticorps AI194338, anticorps Sna, anticorps Sna1, anticorps Snail, anticorps Snail1, anticorps SNAI1, anticorps BG:DS01845.1, anticorps CG3956, anticorps Dmel\\CG3956, anticorps Sco, anticorps br28, anticorps br29, anticorps l(2)35Db, anticorps l(2)br28, anticorps l(2)br29, anticorps l(3)br28, anticorps l35Db, anticorps sn, anticorps Xsnail, anticorps sna, anticorps snail1, anticorps xSna, anticorps Snai, anticorps sna2, anticorps snail2, anticorps cb643, anticorps sna-1, anticorps sna1, anticorps snai1, anticorps snail1a, anticorps zgc:109820, anticorps snail family transcriptional repressor 1, anticorps snail family zinc finger 1, anticorps snail homolog 1 (Drosophila), anticorps snail, anticorps zinc-finger transcription factor Snail, anticorps snail family zinc finger 1 S homeolog, anticorps protein escargot, anticorps transcription factor protein, anticorps snail zinc finger protein, anticorps snail family zinc finger 1b, anticorps snail family zinc finger 1a, anticorps SNAI1, anticorps Snai1, anticorps sna, anticorps snail, anticorps snai1.S, anticorps LOC410464, anticorps snai1b, anticorps snai1a

Sujet:

Description: Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.

Aliases: SNA, SNAH, SLUGH2, dJ710H13.1, SNAI1

Poids moléculaire: 29 kDa

ID gène: 6615

HGNC: 6615

Pathways: Negative Regulation of intrinsic apoptotic Signaling