TAB2 anticorps

N° du produit ABIN969430

Détail du produit anti-TAB2 anticorps

Antigène: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TAB2 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purification: purified

Immunogène: Purified recombinant fragment of human TAB2 expressed in E. coli.

Clone: 3B5

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-TAB2 (ABIN969430)

Thienpont, Zhang, Postma, Breckpot, Tranchevent, Van Loo, Møllgård, Tommerup, Bache, Tümer, van Engelen, Menten, Mortier, Waggoner, Gewillig, Moreau, Devriendt, Larsen: "Haploinsufficiency of TAB2 causes congenital heart defects in humans." dans: American journal of human genetics, Vol. 86, Issue 6, pp. 839-49, (2010) (PubMed).

Häcker, Karin: "Regulation and function of IKK and IKK-related kinases." dans: Science's STKE : signal transduction knowledge environment, Vol. 2006, Issue 357, pp. re13, (2006) (PubMed).

Simmonds, Heward, Carr-Smith, Foxall, Franklyn, Gough: "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease." dans: The Journal of clinical endocrinology and metabolism, Vol. 91, Issue 3, pp. 1056-61, (2006) (PubMed).

Détails sur TAB2

Antigène: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Autre désignation: TAB2 (TAB2 Produits)

Sujet:

Description: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.

Aliases: CHTD2, FLJ21885, KIAA0733, MAP3K7IP2, TAB2

Poids moléculaire: 80 kDa

ID gène: 23118

HGNC: 23118

Pathways: TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway