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CREB1 anticorps (pSer133)

CREB1 Reactivité: Humain WB, IHC, ELISA, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN97863
  • Antigène Voir toutes CREB1 Anticorps
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Épitope
    • 66
    • 29
    • 20
    • 17
    • 16
    • 16
    • 10
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 122-147, pSer133
    Reactivité
    • 291
    • 214
    • 180
    • 33
    • 24
    • 18
    • 17
    • 14
    • 12
    • 10
    • 9
    • 8
    • 8
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 264
    • 29
    • 1
    • 1
    Lapin
    Clonalité
    • 239
    • 56
    Polyclonal
    Conjugué
    • 148
    • 16
    • 14
    • 12
    • 12
    • 11
    • 11
    • 11
    • 11
    • 10
    • 10
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    Cet anticorp CREB1 est non-conjugé
    Application
    • 224
    • 99
    • 98
    • 73
    • 56
    • 56
    • 48
    • 47
    • 19
    • 17
    • 17
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)
    Attributs du produit
    Concentration Definition: by UV absorbance at 280 nm
    Immunogène
    CREB phospho peptide corresponding to amino acid residues 122-147 of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
    Isotype
    IgG
    Top Product
    Discover our top product CREB1 Anticorps primaire
  • Indications d'application
    This phospho specific polyclonal antibody reacts with phosphorylated human CREB at pS133 and shows minimal reactivity by western blot with non-phosphorylated CREB and minimal reactivity (1%) by ELISA against the non-phosphorylated form of the immunizing peptide.  This antibody was assayed against a variety of tissues including fibroblasts and B-cell lysates.  Bands of 46 and 43 kDa corresponding to phosphorylated CREB are observed in western blots.  Anti-CREB pS133 is suitable for the detection by immunoblot of phosphoryl-ated human, mouse and rat CREB.  No cross-reactivity occurs with non-phosphorylated CREB.  For immunohistochemistry, formalin fixed, paraffin embedded human tissue shows moderate to strong nuclear staining in a variety of cells with minimal background staining.  Although not tested this antibody is likely functional by FACS and immunoprecipitation.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.064 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Philp, Chen, Lan, Meyer, Murphy, Knapp, Olfert, McCurdy, Marcotte, Hogan, Baar, Schenk et al.: "Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following ..." dans: The Journal of biological chemistry, Vol. 286, Issue 35, pp. 30561-70, (2011) (PubMed).

  • Antigène
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    Autre désignation
    CREB (CREB1 Produits)
    Synonymes
    anticorps creb, anticorps CREB1, anticorps Creb1, anticorps CREB, anticorps 2310001E10Rik, anticorps 3526402H21Rik, anticorps AV083133, anticorps Creb, anticorps Creb-1, anticorps creb1, anticorps zgc:55598, anticorps cAMP responsive element binding protein 1, anticorps cAMP responsive element binding protein, anticorps cAMP responsive element binding protein 1 S homeolog, anticorps cAMP responsive element binding protein 1a, anticorps CREB1, anticorps creb1, anticorps CREB, anticorps Creb1, anticorps creb1.S, anticorps creb1a
    Sujet
    The CREB (Cyclic AMP-response-element-binding-protein 1) gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element (CRE element TGANNTCA), an octameric palindrome. Phosphorylation by cAMP-dependent protein kinase (PKA) at serine-119 is required for interaction with DNA and phosphorylation at serine-133 allows CREB to interact with CBP (CREB binding protein) leading to interaction with RNA polymerase II.  Alternate splicing of this gene results in two transcript variants encoding different isoforms.
    Synonyms: Active transcription factor CREB antibody, cAMP response element binding protein antibody, cAMP responsive element binding protein 1 antibody, CREB 1 antibody, CREB1 antibody, MGC9284 antibody, Transactivator protein antibody
    ID gène
    1385
    UniProt
    P16220
    Pathways
    Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
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