CREB1 anticorps (N-Term)

N° du produit ABIN97864

Détail du produit anti-CREB1 anticorps

Antigène: CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CREB1 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: CREB-1 (p43) peptide corresponding to a region near the of the human protein, conjugated to Keyhole Limpet Hemocyanin (KLH).

Information d'application

Indications d'application: This product was assayed against a lysate of 1 x 10^6 Raji B cells by immunoblot and found to be reactive against CREB-1 (p43), showing a 46 kDa band at a dilution of 1:500 to 1:1,000 followed by reaction with Peroxidase conjugated Affinity Purified anti-Rabbit IgG (H&L) [Goat] Anti-CREB-1 (p43) is suitable for detection by immunoblot of human, mouse and rat CREB-1 (p43). This product was also tested in a gel supershift assay and found to be reactive against CREB-1 (p43) using 0.5 to 1.0 µl per assay. 

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 2.56 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-CREB1 (ABIN97864)

Chen, Garvin, Nickola, Watson, Colberg-Poley, Rose: "IL-1β induction of MUC5AC gene expression is mediated by CREB and NF-κB and repressed by dexamethasone." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 306, Issue 8, pp. L797-807, (2014) (PubMed).

Wierda, Kuipers, van Eggermond, Benard, van Leeuwen, Carluccio, Geutskens, Jukema, Marquez, Quax, van den Elsen: "Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors." dans: Journal of cellular and molecular medicine, Vol. 16, Issue 8, pp. 1866-77, (2012) (PubMed).

Wang, Sasaki, Zhou, Matsumura, Araki, Mezawa, Takai, Chen, Ogata: "Transcriptional regulation of bone sialoprotein gene by interleukin-11." dans: Gene, (2011) (PubMed).

Philp, Chen, Lan, Meyer, Murphy, Knapp, Olfert, McCurdy, Marcotte, Hogan, Baar, Schenk et al.: "Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following ..." dans: The Journal of biological chemistry, Vol. 286, Issue 35, pp. 30561-70, (2011) (PubMed).

Détails sur CREB1

Antigène: CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))

Autre désignation: CREB-1 (CREB1 Produits)

Synonymes: anticorps creb, anticorps CREB1, anticorps Creb1, anticorps CREB, anticorps 2310001E10Rik, anticorps 3526402H21Rik, anticorps AV083133, anticorps Creb, anticorps Creb-1, anticorps creb1, anticorps zgc:55598, anticorps cAMP responsive element binding protein 1, anticorps cAMP responsive element binding protein, anticorps cAMP responsive element binding protein 1 S homeolog, anticorps cAMP responsive element binding protein 1a, anticorps CREB1, anticorps creb1, anticorps CREB, anticorps Creb1, anticorps creb1.S, anticorps creb1a

Sujet: Anti CREB-1 Antibody recognizes CREB (cAMP response element-binding), a cellular transcription factor. CREB binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the downstream genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose transcription is regulated by CREB include: c-fos, the neurotrophin BDNF (Brain-derived neurotrophic factor), tyrosine hydroxylase, and many neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone). CREB is closely related in structure and function to CREM (cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many animals, including humans. CREB has a well-documented role in neuronal plasticity and long-term memory formation in the brain.
Synonyms: Cyclic AMP-responsive element-binding protein 1 cAMP-responsive element-binding protein 1 CREB-1 CREB1

ID gène: 1385

UniProt: P16220

Pathways: Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation