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CASP8 deficiency is a novel cause of very early onset-inflammatory bowel disease associated with lymphocyte dysfunction, impaired inflammasome activation, and defec- tive epithelial cell death responses.
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Data show that ionizing radiation (IR) induces apoptosis in THP-1 cells through cas-8-mediated pathways, whereas THP-1-derived macrophages (THP-1-M) are resistant to IR due to impaired casp-8-mediated apoptosis during differentiation and not to a capacity for DSB repair suggesting that the regulation of casp-8-mediated apoptosis during differentiation plays a role in the p53-independent radio-resistance of THP-1-M.
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The apoptosis was partially dependent upon caspase-8 concomitant with attenuated NF-kappa B survival signal due to stimulus of TNF-alpha. It suggests that PAK4 as target is a switch between caspase-8 apoptosis and NF-kappa B survival signals induced by TNF-alpha in hepatocarcinoma cells.
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The caspase 8 mediated RIPK1 cleavage product has a pro-apoptotic function, and further cleavage of this pro-apoptotic cleavage product by human rhinovirus 3C protease may provide a mechanism by which human rhinovirus limits apoptosis.
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results suggest that miR-21 regulates the apoptosis of keloid fibroblasts via targeting FasL, and caspase-8 and the mitochondria-mediated apoptotic signaling pathway is involved in this process.
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Caspase-3 and -8 and annexin V may serve as diagnostic markers in Ovarian cancer , also explained that the decrement in control of the S phase in the cell cycle may considered one of the significant factors in the development of ovarian tumors
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neither rs13416436 nor rs2037815 associated with pre-eclampsia
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High CASP8 expression is associated with Colorectal Cancer.
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Sleep duration is associated with plasma caspase-8. Caspase-8 independently predicts diabetes mellitus years before disease onset and modifies the effect of sleep duration on incident diabetes mellitus.
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Caspase-8 and Caspase-3 expressions in tumor tissues are novel candidate prognostic markers for colorectal cancer patients
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Reactive oxygen species-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cells.
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this study is the first report on reduced expression of CASP8 in breast cancer versus adjacent normal tissues.
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The polymorphisms of CASP8, rs7608692, and haplotype AGAACAG correlated with neutropenia toxicity. The haplotype GGGGAAA was associated with thrombocytopenia toxicity. We conclude that the polymorphisms of CASP8 contribute to the prognosis of advanced lung adenocarcinoma and influence the quality of life and survival.
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These results indicated that cMyc and Fas regulated the sensitivity of A549 cells to irradiation by regulating caspase8-mediated Bid activation and the subsequent association with the mitochondrial pathway of apoptosis.
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The caspase-8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production.
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miR-21 was elevated in osteosarcoma, and overexpression of miR-21 suppressed apoptosis via targeting caspase 8.
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Our findings indicate the relationship of SNP CASP8 D302H and breast cancer would not be universal but only be sensitive in some particular European countries.
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no mutations were detected in the CASP8 gene, but we observed a frequent [32/48 (66.6%)] SNP [rs1045487] in the oral cancer samples.
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case-control study, including 600 hepatocellular carcinoma (HCC) and 600 HBsAg positive controls without HCC, was conducted to assess the relationship between 11 tagging SNPs in CASP8, CASP10 and CFLAR and HBV-related HCC risk .These results suggest that the CASP8 -652 6N ins/del polymorphism may play a protective role in the development, progression, and survival of HBV-related HCC among the Chinese Han population.
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High caspase-8 is not significantly associated with adverse breast cancer-specific survival. No associations were observed between caspase-8 and clinicopathological criteria.
