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anti-Mouse (Murine) Caspase 8 Anticorps:
anti-Rat (Rattus) Caspase 8 Anticorps:
anti-Human Caspase 8 Anticorps:
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Gerbil Polyclonal Caspase 8 Primary Antibody pour ICC, IHC (fro) - ABIN252118
Lavrik, Golks, Krammer: Caspases: pharmacological manipulation of cell death. dans The Journal of clinical investigation 2005
Show all 36 Pubmed References
Human Polyclonal Caspase 8 Primary Antibody pour IF (cc), IF (p) - ABIN724205
Wu, Tang, Jiang, Li, Jiang, Liu: PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway. dans Molecular and cellular biochemistry 2011
Show all 11 Pubmed References
Human Polyclonal Caspase 8 Primary Antibody pour IHC (p), WB - ABIN3044129
Jiang, Li, Zhou, Wang, Zhang, Wang: Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways. dans International journal of molecular medicine 2014
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Human Polyclonal Caspase 8 Primary Antibody pour IHC (p), WB - ABIN3044432
Yan, Liang, Zhang, Liu, Bu: Apoptotic induction of lung adenocarcinoma A549 cells infected by recombinant RVG Newcastle disease virus (rL-RVG) in vitro. dans Molecular medicine reports 2014
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Human Polyclonal Caspase 8 Primary Antibody pour WB - ABIN3044361
Zhan, Hu, Yi, An, Huang: Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. dans Molecular medicine reports 2015
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Mouse (Murine) Polyclonal Caspase 8 Primary Antibody pour WB - ABIN3042601
Shan, Li, Newton, Zhao, Li, Guo: A novel protein extracted from foxtail millet bran displays anti-carcinogenic effects in human colon cancer cells. dans Toxicology letters 2014
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Human Monoclonal Caspase 8 Primary Antibody pour ICC, IP - ABIN1168996
Scaffidi, Medema, Krammer, Peter: FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b. dans The Journal of biological chemistry 1997
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Human Monoclonal Caspase 8 Primary Antibody pour WB - ABIN967337
Boesen-de Cock, Tepper, de Vries, van Blitterswijk, Borst: Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation. dans The Journal of biological chemistry 1999
Show all 6 Pubmed References
Human Monoclonal Caspase 8 Primary Antibody pour CyTOF, FACS - ABIN252488
Berges, Fuchs, Opelz, Daniel, Naujokat: Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms. dans Molecular immunology 2009
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Human Monoclonal Caspase 8 Primary Antibody pour IP, WB - ABIN967335
Cock, Tepper, de Vries, van Blitterswijk, Borst: CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase. dans The Journal of biological chemistry 1998
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Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (Montrer AMD1 Anticorps)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (Montrer TP53 Anticorps)-overexpressed apoptotic embryos.
tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (Montrer BID Anticorps) and Caspases-2 and -8
Results illustrate the temporal and spatial activation of caspase-8 and -3 in microglia/macrophages occurring upon ischemic stroke and suggest that the expression of these caspases could be used in neuropathological diagnostic work.
inhibition of TAK1 (Montrer NR2C2 Anticorps) triggered two caspase 8 activation pathways through the induction of RIP1 (Montrer RALBP1 Anticorps)-FADD (Montrer FADD Anticorps)-caspase 8 complex as well as FLIP cleavage/degradation.
this study identifies a crucial role for caspase-8 in the development of allergic airway inflammation
Prolonged treatment of human PMNs or mice bone marrow derived neutrophils (BMDN) with nitric oxide led to enhanced reactive oxygen species generation, caspase-8/caspase-3 (Montrer CASP3 Anticorps) cleavage, reduced mitochondrial membrane potential and finally cellular apoptosis.
caspase-8-dependent apoptosis was linked to hepatocellular carcinoma development.
Statistically significant increases in the expression of Fas (Montrer FAS Anticorps) and caspase-8 were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1 (Montrer DAPK1 Anticorps), Traf3 (Montrer TRAF3 Anticorps), Tnsf12, Tnfrsf1A (Montrer TNFRSF1A Anticorps) and Ripk1 (Montrer RIPK1 Anticorps).
Results suggest that caspase-8 could regulate receptor-interacting protein 3 (RIP3 (Montrer RIPK3 Anticorps))-mediated necroptosis.
we show that caspase-8 activity promotes cell-intrinsic cytokine expression, independent of its role in cell death in response to Yersinia infection
Data indicate that NLRC4 (Montrer NLRC4 Anticorps) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (Montrer IL18 Anticorps) release, and implicate Caspase-8 in NLRC4 (Montrer NLRC4 Anticorps) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (Montrer CASP1 Anticorps) and Caspase-8.
ING4 (Montrer ING4 Anticorps) might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas (Montrer FAS Anticorps)-induced apoptosis in a caspase-8-dependent pathway.
miR (Montrer MLXIP Anticorps)-21 was elevated in osteosarcoma, and overexpression of miR (Montrer MLXIP Anticorps)-21 suppressed apoptosis via targeting caspase 8.
Our findings indicate the relationship of SNP CASP8 D302H and breast cancer would not be universal but only be sensitive in some particular European countries.
no mutations were detected in the CASP8 gene, but we observed a frequent [32/48 (66.6%)] SNP [rs1045487] in the oral cancer samples.
case-control study, including 600 hepatocellular carcinoma (HCC) and 600 HBsAg positive controls without HCC, was conducted to assess the relationship between 11 tagging SNPs in CASP8, CASP10 and CFLAR and HBV-related HCC risk .These results suggest that the CASP8 -652 6N ins/del polymorphism may play a protective role in the development, progression, and survival of HBV-related HCC among the Chinese Han population.
High caspase-8 is not significantly associated with adverse breast cancer-specific survival. No associations were observed between caspase-8 and clinicopathological criteria.
we found that plumbagin could enhance TRAIL-induced apoptosis in Kasumi-1 cells, and the mechanisms include ROS (Montrer ROS1 Anticorps)-mediated upregulation of DR5 (Montrer TNFRSF10B Anticorps) expression, caspase-8 activation and inhibition of cFLIP (Montrer CFLAR Anticorps) expression
this study shows that mitochondrial DNA oxidation induces imbalanced activity of NLRP3 (Montrer NLRP3 Anticorps)/NLRP6 (Montrer NLRP6 Anticorps) inflammasomes by activation of caspase-8 and BRCC36 (Montrer BRCC3 Anticorps) in dry eye
Importantly, the bioinformatics analysis of microarray gene expression data derived from a set of high-grade human gliomas, shows that high Caspase-8 expression levels correlate with a worse prognosis.
this review describes the role of caspase-8 in the initiation of extrinsic apoptosis execution and the mechanism by which caspase-8 inhibits necroptosis
Data indicate that elevated levels of Polo-like kinase 3 (Plk3 (Montrer PLK3 Anticorps))and pT273 caspase-8 are correlated with favorable clinical outcome in patients with anal squamous cell carcinoma (anal SCC (Montrer CYP11A1 Anticorps)) treated with concomitant chemoradiotherapy (CRT (Montrer SLC6A8 Anticorps)).
S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (Montrer CASP3 Anticorps) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.
Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (Montrer CASP9 Anticorps).
Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (Montrer STAT1 Anticorps) at Ser (Montrer SIGLEC1 Anticorps)-727 and STAT1 (Montrer STAT1 Anticorps) binding to the caspase-8 promoter in cultured lung endothelial cells.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (Montrer TNF Anticorps), IL-6 (Montrer IL6 Anticorps), IL-12p40, IL-1beta (Montrer IL1B Anticorps), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (Montrer BCL2L1 Anticorps).
Induction of apoptosis through targeted activation of caspase (Montrer CASP3 Anticorps) by tamoxifen (ATTAC(TM)) further expands the repertoire of genetic tools for conditional interrogation of cellular functions.
Targeted gene knockdown of TNFRSF1B (Montrer TNFRSF1B Anticorps) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (Montrer CASP2 Anticorps) and P53 (Montrer TP53 Anticorps)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (Montrer CASP3 Anticorps).
These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
, xcaspase 8
, death related ced-3/Nedd2-like protein
, caspase 8, apoptosis-related cysteine peptidase
, caspase 8
, DEATH effector domain caspase
, Fas-linked ICE-like protease
, FADD-homologous ICE/CED-3-like protease
, FADD-like ICE
, ICE-like apoptotic protease 5
, MACH-alpha-1/2/3 protein
, MACH-beta-1/2/3/4 protein
, MORT1-associated ced-3 homolog
, apoptotic cysteine protease
, apoptotic protease Mch-5
, caspase 8, apoptosis-related cysteine protease
, cysteine protease