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anti-Human CYLD Anticorps:
anti-Mouse (Murine) CYLD Anticorps:
anti-Rat (Rattus) CYLD Anticorps:
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Mouse (Murine) Polyclonal CYLD Primary Antibody pour ELISA, WB - ABIN188848
Massoumi, Chmielarska, Hennecke, Pfeifer, Fässler: Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. dans Cell 2006
Cow (Bovine) Polyclonal CYLD Primary Antibody pour ICC, IF - ABIN410065
Wu, Mu, Gao, Wang, Sy, Li: Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production. dans The Journal of biological chemistry 1970
Human Polyclonal CYLD Primary Antibody pour ICC, IF - ABIN252428
Moranta, Regueiro, March, Llobet, Margareto, Larrarte, Larrate, Garmendia, Bengoechea: Klebsiella pneumoniae capsule polysaccharide impedes the expression of beta-defensins by airway epithelial cells. dans Infection and immunity 2010
theses data show that CYLD regulates the magnitude of ubiquitination of several major effectors of the EGFR (Montrer EGFR Anticorps) pathway by assisting the recruitment of the ubiquitin ligase Cbl-b to the activated EGFR (Montrer EGFR Anticorps) complex.
Through deceasing the expression of Cylindromatosis (CYLD), a K63-specific DUB and endogenous blocker of NF-kappaB (Montrer NFKB1 Anticorps) signaling, miR (Montrer MLXIP Anticorps)-130b can in return sustain the persistent activation of NF-kappaB (Montrer NFKB1 Anticorps), which may promote the malignant progression of transitional cell carcinoma of bladder.
While previous reports have described CYLD as a regulator of DVL proteins; this data suggests the presence of a more complicated reciprocal regulatory mechanism in CML cell lines.
Thrombin (Montrer F2 Anticorps)-mediated MALT1 (Montrer MALT1 Anticorps) protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage.
MiR (Montrer MLXIP Anticorps)-767 acted as a role of tumor promoter by targeting CYLD in human melanoma.
SPATA2 (Montrer SPATA2 Anticorps) has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP (Montrer RNF31 Anticorps) and CYLD, thereby enabling recruitment of CYLD to signaling complexes.
The data reveal SPATA2 (Montrer SPATA2 Anticorps) as a high-affinity binding partner of CYLD and HOIP (Montrer RNF31 Anticorps), and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (Montrer NFKB1 Anticorps) signaling.
The current investigations identified a subset of HPV-positive HNSCCs with mutations in the genes TRAF3 (Montrer TRAF3 Anticorps) (tumor necrosis factor (Montrer TNF Anticorps) receptor-associated factor 3) and CYLD (cylindromatosis lysine 63 deubiquitinase). Defects in TRAF3 (Montrer TRAF3 Anticorps) and CYLD correlated with the activation of transcriptional factor nuclear factor kappaB, episomal HPV status of tumors, and improved patient survival.
The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes.
STAT3 (Montrer STAT3 Anticorps) and miR (Montrer MLXIP Anticorps)-181b control each other's expression in a positive feedback loop that regulates SFCs via CYLD pathway.
Findings provide physiological insight into the ciliary role of the CYLD/HDAC6 (Montrer HDAC6 Anticorps) axis and suggest a functional interplay between these two proteins in ciliary homeostasis.
TLR4 (Montrer TLR4 Anticorps) activates CASPASE-8 (Montrer CASP8 Anticorps) to cleave and remove the deubiquitinase cylindromatosis (CYLD) in a TRIF (Montrer RNF138 Anticorps)- and RIPK1 (Montrer RIPK1 Anticorps)-dependent manner to disable necroptosis in macrophages.
CYLD contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 (Montrer NOX4 Anticorps) and may play a role in vascular remodeling.
this study shows that by polarization of the T cell cytokine response, CYLD can favor the development of allergic airway disease
Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis
Deubiquitinase CYLD negatively regulates MyD88 (Montrer MYD88 Anticorps)-mediated signaling by directly interacting with MyD88 (Montrer MYD88 Anticorps) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (Montrer MYD88 Anticorps) at lysine 231.
CYLD interrupts the ERK (Montrer EPHB2 Anticorps)- and p38 (Montrer CRK Anticorps)-/AP-1 (Montrer JUN Anticorps) and c-Myc (Montrer MYC Anticorps) pathways to suppress Nrf2 (Montrer NFE2L2 Anticorps)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.
Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.
The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (Montrer DNMT1 Anticorps)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (Montrer DNMT1 Anticorps)-linked chains are presented.
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
deubiquitinating enzyme CYLD
, probable ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin specific peptidase like 2
, ubiquitin thioesterase CYLD
, ubiquitin thiolesterase CYLD
, ubiquitin-specific-processing protease CYLD
, cylindromatosis (turban tumor syndrome)
, probable ubiquitin carboxyl-terminal hydrolase CYLD-like
, retinitis pigmentosa 1 homolog