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anti-Human CYLD Anticorps:
anti-Mouse (Murine) CYLD Anticorps:
anti-Rat (Rattus) CYLD Anticorps:
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Mouse (Murine) Polyclonal CYLD Primary Antibody pour ELISA, WB - ABIN188848
Massoumi, Chmielarska, Hennecke, Pfeifer, Fässler: Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. dans Cell 2006
Cow (Bovine) Polyclonal CYLD Primary Antibody pour ICC, IF - ABIN410065
Wu, Mu, Gao, Wang, Sy, Li: Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production. dans The Journal of biological chemistry 1970
Human Polyclonal CYLD Primary Antibody pour ICC, IF - ABIN252428
Moranta, Regueiro, March, Llobet, Margareto, Larrarte, Larrate, Garmendia, Bengoechea: Klebsiella pneumoniae capsule polysaccharide impedes the expression of beta-defensins by airway epithelial cells. dans Infection and immunity 2010
Polyclonal CYLD Primary Antibody pour WB - ABIN540750
Hellerbrand, Bumes, Bataille, Dietmaier, Massoumi, Bosserhoff: Reduced expression of CYLD in human colon and hepatocellular carcinomas. dans Carcinogenesis 2006
Studied the role of maternally expressed 3 (lncRNA-MEG3 (Montrer FAM129B Anticorps)) as an antitumor lncRNA for malignant melanoma by regulating miR (Montrer MLXIP Anticorps)-499-5p/CYLD axis.
CYLD inhibits post-transcriptional regulation of RIG-I (Montrer DDX58 Anticorps) and MDA5 (Montrer IFIH1 Anticorps) expression following TLR3 (Montrer TLR3 Anticorps) activation in MCs (Montrer SMCP Anticorps). CYLD may be involved in the pathogenesis of CKD
miR (Montrer MLXIP Anticorps)-197-3p-induced downregulation of CYLD promotes cell proliferation and inhibits cell apoptosis in lung adenocarcinoma cell lines.
Knockdown of CYLD expression reversed the cell proliferation promotion by miR1288in in glioblastoma.
TNF (Montrer TNF Anticorps) phase III signalling displays ongoing TNFR1 (Montrer TNFRSF1A Anticorps)/NF-kappa B (Montrer NFKB1 Anticorps) activation in monocytic cells. High- and low-sensitive genes are induced including differentially regulated A20 (Montrer TNFAIP3 Anticorps). A20 (Montrer TNFAIP3 Anticorps) strictly controls this signalling in an IKK (Montrer CHUK Anticorps)- and partially RIP (Montrer HRB Anticorps)-dependent manner. The A20 (Montrer TNFAIP3 Anticorps)-mediated control mechanisms are supported by ABIN1 (Montrer TNIP1 Anticorps) and CYLD.
Low expression of CYLD is associated with glioma.
theses data show that CYLD regulates the magnitude of ubiquitination of several major effectors of the EGFR (Montrer EGFR Anticorps) pathway by assisting the recruitment of the ubiquitin ligase Cbl-b to the activated EGFR (Montrer EGFR Anticorps) complex.
Through deceasing the expression of Cylindromatosis (CYLD), a K63-specific DUB and endogenous blocker of NF-kappaB (Montrer NFKB1 Anticorps) signaling, miR (Montrer MLXIP Anticorps)-130b can in return sustain the persistent activation of NF-kappaB (Montrer NFKB1 Anticorps), which may promote the malignant progression of transitional cell carcinoma of bladder.
While previous reports have described CYLD as a regulator of DVL proteins; this data suggests the presence of a more complicated reciprocal regulatory mechanism in CML cell lines.
Thrombin (Montrer F2 Anticorps)-mediated MALT1 (Montrer MALT1 Anticorps) protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage.
Loss of CYLD catalytic activity causes impaired DNA damage-induced p53 (Montrer TP53 Anticorps) stabilization and activation in epithelial cells and sensitizes mice to chemical carcinogen-induced intestinal and skin tumorigenesis.
The present results support the involvement of CYLD in the regulation of NF-kappaB (Montrer NFKB1 Anticorps) inflammatory signaling induced by elevated glucose, implicating CYLD as a potential therapeutic target of diabetic nephropathy .
the role of CYLD in development, tissue homeostasis, and tumorigenesis
Findings provide physiological insight into the ciliary role of the CYLD/HDAC6 (Montrer HDAC6 Anticorps) axis and suggest a functional interplay between these two proteins in ciliary homeostasis.
SPATA2 (Montrer SPATA2 Anticorps) has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP (Montrer RNF31 Anticorps) and CYLD, thereby enabling recruitment of CYLD to signaling complexes.
TLR4 (Montrer TLR4 Anticorps) activates CASPASE-8 (Montrer CASP8 Anticorps) to cleave and remove the deubiquitinase cylindromatosis (CYLD) in a TRIF (Montrer RNF138 Anticorps)- and RIPK1 (Montrer RIPK1 Anticorps)-dependent manner to disable necroptosis in macrophages.
CYLD contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 (Montrer NOX4 Anticorps) and may play a role in vascular remodeling.
this study shows that by polarization of the T cell cytokine response, CYLD can favor the development of allergic airway disease
Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis
The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (Montrer DNMT1 Anticorps)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (Montrer DNMT1 Anticorps)-linked chains are presented.
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
deubiquitinating enzyme CYLD
, probable ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin carboxyl-terminal hydrolase CYLD
, ubiquitin specific peptidase like 2
, ubiquitin thioesterase CYLD
, ubiquitin thiolesterase CYLD
, ubiquitin-specific-processing protease CYLD
, cylindromatosis (turban tumor syndrome)
, probable ubiquitin carboxyl-terminal hydrolase CYLD-like
, retinitis pigmentosa 1 homolog