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Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They contiguously tile the entire central nervous system (CNS) and exert many essential complex functions in the healthy CNS. Astrocytes respond to all forms of CNS insults through a process referred to as reactive astrogliosis, which has become a pathological hallmark of CNS structural lesions. Substantial progress has been made recently in determining functions and mechanisms of reactive astrogliosis and in identifying roles of astrocytes in CNS disorders and pathologies.(1)
antibodies-online offers an excellent selection of antibodies, kits and tools for the investigation of astrocytes. Below you will find hand-picked, reliable products for some of the important targets.
The following targets are directly related to research on Astrocytes. Click on the links to see all available products.
Glial fibrillary acidic protein (GFAP) is one of the best markers for the activation of astrocytes following injury or stress in the central nervous system.(2) Culturing neurons and AS together show that local inflammatory response is significantly enhanced by inhibiting GFAP production. GFAP inhibition increased neuronal death, suggesting the protective effects of GFAP in the nervous system injury.(3)
Below you will find our best-selling monoclonal GFAP antibodies with human and mouse reactivity. Click on a link to see available PubMed references, images and more product details.
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Here you will find a range of reliable ELISA kits with PubMed references, which allow a quick and easy detection of related targets in biological samples. Click on the links to find more information.
(1) Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol. 2010 Jan;119(1):7-35. doi: 10.1007/s00401-009-0619-8. Epub 2009 Dec 10. PMID: 20012068; PMCID: PMC2799634.
(2) Zhang S, Wu M, Peng C, Zhao G, Gu R. GFAP expression in injured astrocytes in rats. Exp Ther Med. 2017 Sep;14(3):1905-1908. doi: 10.3892/etm.2017.4760. Epub 2017 Jul 10. PMID: 28962102; PMCID: PMC5609138.
(3) Lefrançois T, Fages C, Peschanski M, Tardy M. Neuritic outgrowth associated with astroglial phenotypic changes induced by antisense glial fibrillary acidic protein (GFAP) mRNA in injured neuron-astrocyte cocultures. J Neurosci. 1997 Jun 1; 17(11):4121-8.