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anti-Human PLAT Anticorps:
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Mouse (Murine) Polyclonal PLAT Primary Antibody pour ELISA (Detection), IHC (fro) - ABIN491324
Bi Oh, Suh, Kim, Lee: Impacts of aging and amyloid-? deposition on plasminogen activators and plasminogen activator inhibitor-1 in the Tg2576 mouse model of Alzheimer's disease. dans Brain research 2015
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Mouse (Murine) Polyclonal PLAT Primary Antibody pour ELISA (Detection), WB - ABIN491292
Bavelloni, Piazzi, Raffini, Faenza, Blalock: Prohibitin 2: At a communications crossroads. dans IUBMB life 2015
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Human Polyclonal PLAT Primary Antibody pour ELISA (Detection), IHC (fro) - ABIN491321
Pawlak, Melchor, Matys, Skrzypiec, Strickland: Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors. dans Proceedings of the National Academy of Sciences of the United States of America 2005
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Mouse (Murine) Polyclonal PLAT Primary Antibody pour AC, ELISA (Capture) - ABIN491261
Fredriksson, Stevenson, Su, Ragsdale, Moore, Craciun, Schielke, Murphy, Lawrence: Identification of a neurovascular signaling pathway regulating seizures in mice. dans Annals of clinical and translational neurology 2015
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Mouse (Murine) Polyclonal PLAT Primary Antibody pour ELISA (Detection), WB - ABIN490939
Dahlem, Bos, Haitsma, Schultz, Wolthuis, Meijers, Lachmann: Mechanical ventilation affects alveolar fibrinolysis in LPS-induced lung injury. dans The European respiratory journal 2006
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Mouse (Murine) Polyclonal PLAT Primary Antibody pour AC, ELISA (Detection) - ABIN491312
Wu, Torre, Cuellar-Giraldo, Cheng, Yi, Bichler, García, Yepes: Tissue-type plasminogen activator triggers the synaptic vesicle cycle in cerebral cortical neurons. dans Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015
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Human Polyclonal PLAT Primary Antibody pour IF (p), IHC (p) - ABIN731123
Balaoing, Post, Liu, Minn, Grande-Allen: Age-related changes in aortic valve hemostatic protein regulation. dans Arteriosclerosis, thrombosis, and vascular biology 2013
Mouse (Murine) Polyclonal PLAT Primary Antibody pour ELISA (Detection), IHC (fro) - ABIN491323
Giacobini, Messina, Wray, Giampietro, Crepaldi, Carmeliet, Fasolo: Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migration. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Mouse (Murine) Monoclonal PLAT Primary Antibody pour ELISA (Capture), ELISA (Detection) - ABIN491258
Zhang, Kanaho, Frohman, Tsirka: Phospholipase D1-promoted release of tissue plasminogen activator facilitates neurite outgrowth. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
We reported for the first time to our knowledge the significant role of the two SNPs in t-PA gene (rs2020918 and rs4646972) in developing susceptibility to temporal lobe epilepsyin Chinese Han population
this study shows hypermethylation of PLAT promoter may downregulate the gene expression in nasal polyps, leading to excessive fibrin deposition by aberrant coagulation cascade
These findings provides evidence that gene-gene interactions between p11, tPA and BDNF are all associated with post stroke depression.
PAI-1/tPA ratio may be an important parameter to monitor the progression of OSMF, and normalizing this ratio to 1:1 may reinstate the normal healing pattern in OSMF cases
The concentration of tPA/PAI-1 complex is an independent predictor of mortality from all causes and from cardiovascular causes in patients with heart failure and preserved ejection fraction.
Underexpression of Tissue plasminogen activator is associated with diabetic foot syndrome.
By mediating the tPA response in macrophages, the NMDA-R provides a pathway by which the fibrinolysis system may regulate innate immunity.
Data suggest that protein aggregates interact with tissue-type plasminogen activator and plasminogen to efficiently generate plasmin; this aggregate-bound plasmin is shielded from inhibition by alpha-2-antiplasmin and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).
Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of intracranial aneurysms.
tPA is a ligand of the N-terminal domain of the obligatory GluN1 subunit of NMDAR acting as a modulator of their dynamic distribution at the neuronal surface and subsequent signaling.
t-PA binds to Lys91 in the MBP NH2-terminal region and PLGbinds to Lys122 in the MBP COOH-terminal region. This proximity promotes the activation of Pg by t-PA.
local accumulation of cortisol is a causative factor for amnion epithelial apoptosis via activation of tPA/plasmin system toward the end of gestation. This may contribute to the ROM at both term and preterm birth.
We identified a homozygous null mutation in PLAT that abrogated t-PA level in patient cells. This is the first reported human knockout mutation of PLAT. The apparent association with hydranencephaly, diaphragmatic hernia and postnatal lethality requires further validation.
Tissue plasminogen activator (t-PA) antigen is a marker of cardiovascular risk. Exercise interventions associated with weight loss reduce t-PA antigen. Endurance training per se reduces t-PA antigen in healthy overweight men.
we reviewed current knowledge of mechanisms by which tPA can influence brain function in physiological and pathological conditions--REVIEW}
This study examines the complexes of PAI-1 with tissue-type and urokinase-type plasminogen activator and vitronectin revealed by changes in the conformation and dynamics of the reactive center loop.
Data suggest that baseline levels of adiponectin, C-reactive protein, TPA, and fibrinogen or changes in these levels do not explain increased risk of diabetes type 2 in overweight women with glucose intolerance and histories of gestational diabetes.
Tissue plasminogen activator (tPA) may be a general factor in the immunological response to viruses.
tPA has a role in progression of periventricular white matter hyperintensities
These data indicate that oxygen-glucose deprivation-triggered Cav-1 S-nitrosylation interacts with tPA-induced ERK activation to augment MMP2 and 9 secretion and subsequent extracellular matrix degradation.
Sata suggest that tissue-type plasminogen activator (tPA) regulates nocturnal wheel-running activity, and that tPA differentially affects suprachiasmatic nucleus-driven nocturnal activity rhythms and activity driven by fasting or temporal food restriction.
Our findings suggest that isoflurane pretreatment could attenuate tPA-exaggerated brain ischemic injury, by reducing tPA-induced LRP/NF-kappaB/Cox-2 in endothelial cells, endothelial MMP-2 and MMP-9 activation, and subsequent pro-apoptotic molecule in neurons after oxygen/glucose deprivation and reperfusion.
Tissue plasminogen activator was found to be restricted to subsets of excitatory pyramidal glutamatergic neurons.
analysis of mutations in genes co-segregating with the targeted Plat allele, including several potential null mutations
A model of sustained hyperfibrinolytic state can be obtained in mice by hydrodynamic transfection of a plasmid encoding for tissue-type plasminogen activator (tPA).
While the absence of t-PA confers a more deleterious form of Experimental Autoimmune Encephalomyelitis, neuronal over-expression of t-PA does not overtly protect against this condition with regards to symptom onset or severity of Experimental Autoimmune Encephalomyelitis.
mesenchymal stromal cells promote axonal outgrowth via neuronal tPA and synergistically with astrocytic tPA
administration of ADAMTS13 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA patency and consequently reduced cerebral infarct sizes
strategies contributing to promote either endogenous production of tPA or its associated EGFR-linked signaling pathway may have beneficial effects following brain injuries such as stroke.
Plasminogen activation contributes to wound repair and suggest that adenosine A2A receptor activation promotes wound closure by a mechanism that depends on tPA.
Myeloid-derived Tissue-type plasminogen activator (tPA) promotes macrophage migration through a novel signaling cascade involving FAK, Rac-1, and NF-kappaB.
the protective effect of neuroserpin maybe independent from its canonical interaction with a tissue-type plasminogen activator
Erythropoietin protects mouse renal tubular basement membrane by promoting bone marrow cells to generate and secrete miR-144, which, in turn, inhibits activation of the tPA/MMP9-mediated proteolytic network.
tPA activity in V1 can be unmasked following 4 d of monocular deprivation when mice older than 2 months are raised in standard cages by the genetic removal of Lynx1, a negative regulator of adult plasticity.
Study shows that the competitive expression or activity of tPA and/or PAI-1, rather than an altered uPA expression, determines the plasmin-mediated Abeta proteolysis in brains affected by Alzheimer's disease
Results demonstrate that synaptic potentiation results in tissue plasminogen activator-dependent reelin processing and suggest that extracellular proteolysis of reelin may regulate reelin signaling in the adult brain
data implicate MCP-1 as the key molecule governing tPA-induced fluid accumulation. The role of MCP-1 in the development of other exudative effusions warrants examination.
Data indicated that suggest that tPA modulates emotion in a social context through the function of the prefrontal cortex.
The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte.
stage-dependent regulation of granulosa cell PA and SerpinE2 production, consistent with a role in extracellular matrix remodeling during follicle growth
These results suggest that Neovastat induces tPA gene transcription through activation of the JNK and NFkappaB signaling pathways, leading to an increase of tPA secretion by endothelial cells.
Mild experimental hypothermia markedly reduces ischemia-related coronary tissue plasminogen activator release, which may contribute to the cardioprotective effect of hypothermia.
a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile
ADP acting on the endothelial P2Y(1) M receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding\; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
, plasminogen activator, tissue type
, t-plasminogen activator
, tissue plasminogen activator (t-PA)
, tissue-type plasminogen activator
, tissue plasminogen activator
, T-plasminogen activator
, plasminogen activator, tissue
, tissue-type plasminogen activator-like