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Following Schistosoma exposure, TSP-1 levels in the lung increase, via recruitment of circulating monocytes, while TSP-1 inhibition or knockout bone marrow prevents TGF-beta activation and protects against pulmonary hypertension development.
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TSP-1 appears to play an accessory role in modulating Mp activity in humans and BlaJ mice in a gender, age and muscle-dependent manner, but is unlikely a primary driver of disease progression of dysferlinopathy.
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TSP-1 may be beneficial for maintaining BBB integrity in the early phase and functional recovery in late phase after traumatic brain injury.
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In a laser injury-induced thrombosis model, P-selectin modulates thrombus propagation independently of VWF and TSP1
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These findings shed light on the mechanisms leading to beta-cell failure during metabolic stress and point to THBS1 as an interesting therapeutic target to prevent oxidative stress in type 2 diabetes.
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cultured astrocytes isolated from an Fmr1 knockout (Fmr1 KO) mouse model of Fragile X syndrome displayed a significant decrease in TSP-1 protein expression compared to the wildtype (WT) astrocytes.
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In pulmonary hypertension TSP1-CD47 is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
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HIF-1alpha induced angiogenesis by upregulating not only vascular endothelial growth factor but also miR-21 via inhibiting a novel target gene TSP-1. Both of them may contribute to the protective effect of HIF-1alpha on renal I/R injury.
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the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1/CD47 axis may represent a valuable therapeutic alternative for hampering melanoma spreading.
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TSP-1 deficiency promotes maladaptive remodelling of the ECM leading to accelerated abdominal aortic aneurysms progression.
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TSP-1 suppressed insulin signaling in cultured muscle cells, which was accompanied by the activation of stress signaling such as JNK, p38, and IKK.
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Three transcription factors were overexpressed and eleven underexpressed in TSP1(-/-) compared to WT LGs.
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Data indicate that thrombospondin-1 may contribute to a destructive macrophage response in dysferlinopathy and pose the intriguing possibility that thrombospondin-1 levels may serve as a biomarker for disease progression.
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demonstrate that HIF-2alpha is clearly implicated in the TSP1 pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction
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Thrombospondin-1 was differentially expressed according to tumor grade, but not affected by p53 expression or mutational status
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Data suggest neutrophil protease- Tsp-1 (thrombospondin-1) axis as a potential antimetastatic therapeutic target.
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These results contribute new insights on the controversial role of TSP-1 in cancer.
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The accumulation and thereby the functionality of thrombospondin in extracellular matrix is controlled by concentration-dependent, intermolecular "matrix trapping" mechanism.
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TSP1 contributes to progression of chronic kidney disease by catalyzing activation of latent TGF-beta1, resulting in promotion of a fibroproliferative response over an inflammatory response.
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Thrombospondin1 deficiency did not affect the development of obesity associated macro-vascular complication in ApoE-/- mice, but attenuated obesity associated micro-vascular complications.
