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Human Vitronectin Protein expressed in Human - ABIN2544423
Gårdsvoll, Jacobsen, Kriegbaum, Behrendt, Engelholm, Østergaard, Ploug: Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction. dans The Journal of biological chemistry 2011
Show all 9 Pubmed References
Human Vitronectin Protein expressed in - ABIN1047972
Seger, Shaltiel: Evidence showing that the two-chain form of vitronectin is produced in the liver by a selective furin cleavage. dans FEBS letters 2000
Human Vitronectin Protein expressed in Human - ABIN491246
Li, Zou, Yuan, Lu: Defining the native disulfide topology in the somatomedin B domain of human vitronectin. dans The Journal of biological chemistry 2007
Mouse (Murine) Vitronectin Protein expressed in Mouse - ABIN491247
Wu, Peng, McMahon, Lawrence, Fay: Recombinant plasminogen activator inhibitor-1 inhibits intimal hyperplasia. dans Arteriosclerosis, thrombosis, and vascular biology 2009
The 10 kDa C-terminal fragment of the ECM (Montrer MMRN1 Protéines) protein vitronectin (VTN) was then selected as a promising circulating biomarker in discriminating Nonalcoholic steatohepatitis.
The authors observed that exposure of Burkholderia pseudomallei and the closely related yet avirulent Burkholderia thailandensis to human plasma increased epithelial cell invasion by >20 fold. Receptor blocking studies with RGD-domain containing peptide and alphaV beta3 blocking antibody identified complement-activated vitronectin as the factor facilitating this invasion.
Additionally, the authors utilized vitroenctin-derived peptides to map the minimal Rickettsia conorii Adr1/human vitronectin interaction to the C-terminal region of vitronectin.
Serum vitronectin levels are elevated in human glioma, as well as are independently associated with pathologic grade based on WHO classification and 5-year poor prognosis. Moreover, this biomarker significantly discriminates gliomas from controls, other non-glioma brain tumors and other non-tumor neurological diseases, distinguishes high-grade gliomas from low-grade gliomas, and predicts 5-year progression and mortality.
Elevated serum VN levels represented high diagnostic value and had close relation to clinicopathological factors and early recurrence, suggesting that serum VN might be a useful diagnostic and prognostic marker for HCC (Montrer FAM126A Protéines).
We confirmed increased levels of C1R (Montrer C1R Protéines) and VTN in sera from patients with Joint hypermobility syndrome by western blot analyses
This study examines the complexes of PAI-1 (Montrer SERPINE1 Protéines) with tissue-type and urokinase-type plasminogen activator (Montrer PLAU Protéines) and vitronectin revealed by changes in the conformation and dynamics of the reactive center loop.
Ail-expressing Yersinia pestis strains bind vitronectin - a host protein with functions in cell attachment, fibrinolysis and inhibition of the complement system.
The mean level of PAI-1 (Montrer SERPINE1 Protéines) was 23.02 +/- 15 (8.2-71.19) ng/mL and vitronectin was 83.10% +/- 23.77% (12%-126%) in the tumor group.
Bacterial protein-E (Montrer CRISP1 Protéines) and host vitronectin play a role in the attachment to bronchial epithelial cells and is also involved in the subsequent intracellular invasion of nontypeable Haemophilus influenzae.
The effects of genetic alterations in PAI-1 (Montrer SERPINE1 Protéines) expression, pharmacologic PAI-1 (Montrer SERPINE1 Protéines) inhibition and recombinant PAI-1 (Montrer SERPINE1 Protéines) on smooth muscle cell vitronectin (VN) expression were studied, and vascular VN expression in wild-type and PAI-1 (Montrer SERPINE1 Protéines)-deficient mice was assessed.
the TGF-beta (Montrer TGFB1 Protéines)-PAI-1 (Montrer SERPINE1 Protéines)-vitronectin-integrin axis may represent a critical convergence of factors in determining the alveolar epithelial cell apoptotic response during lung injury.
In vtn knockout mice, neuronal differentiation in the cerebellum was suppressed compared with wild-type mice.
Elevated levels of TIMP3 and vitronectin, acting downstream of Notch3(ECD) deposition, play a role in CADASIL, producing divergent influences on early CBF deficits and later white matter lesions.
PAI-1 (Montrer SERPINE1 Protéines), through its interaction with Vn, exerts multiple deleterious mechanisms to induce AKI.
These data suggest that adhesion to vitronectin allows for the uncoupling of fibronectin (Montrer FN1 Protéines) fibril formation from downstream signaling events by reducing alpha5beta1 integrin activation and fibronectin (Montrer FN1 Protéines) fibril extension.
Report role of vitronectin in the regulation of angiogenesis induced by VEGF (Montrer VEGFA Protéines).
Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages.
the extracellular matrix molecule VN and its neuronal receptor TLCN (Montrer ICAM5 Protéines) play a pivotal role in the phosphorylation of ezrin/radixin/moesin (Montrer MSN Protéines) proteins and the formation of phagocytic cup-like structures on neuronal dendrites
VN plays a previously unrecognized role in regulating endothelial permeability via conformational- and integrin-dependent effects on VE-cadherin (Montrer CDH5 Protéines) trafficking.
for intact vitronectin the effect of the heparin-binding domain predominates with respect to the signaling events that occur following ligand binding to the alphaVbeta3 integrin
These results imply that the amino acid motif RGD-2 of goat vitronectin is involved in complement C9 binding.
characterization of goat plasma vitronectin
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.
, complement S-protein
, serum spreading factor
, serum-spreading factor
, somatomedin B
, vitronectin (serum spreading factor, somatomedin B, complement S-protein)
, glycoprotein 66
, complement S-protein)