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Human Vitronectin Protein expressed in Human - ABIN2544423
Gårdsvoll, Jacobsen, Kriegbaum, Behrendt, Engelholm, Østergaard, Ploug: Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction. dans The Journal of biological chemistry 2011
Show all 9 Pubmed References
Human Vitronectin Protein expressed in - ABIN1047972
Seger, Shaltiel: Evidence showing that the two-chain form of vitronectin is produced in the liver by a selective furin cleavage. dans FEBS letters 2000
Human Vitronectin Protein expressed in Human - ABIN491246
Li, Zou, Yuan, Lu: Defining the native disulfide topology in the somatomedin B domain of human vitronectin. dans The Journal of biological chemistry 2007
Mouse (Murine) Vitronectin Protein expressed in Mouse - ABIN491247
Wu, Peng, McMahon, Lawrence, Fay: Recombinant plasminogen activator inhibitor-1 inhibits intimal hyperplasia. dans Arteriosclerosis, thrombosis, and vascular biology 2009
Serum miR-99a-5p is significantly elevated in ovarian cancer patients. Exosomal miR-99a-5p from EOC cells promotes cell invasion by affecting HPMCs through fibronectin and vitronectin upregulation and may serve as a target for inhibiting ovarian cancer progression.
Results showed that BPIFB1 expression markedly inhibited NPC cell migration, invasion, and lung-metastatic abilities. Additionally, identification of two BPIFB1-interacting proteins, VTN and VIM, showed that BPIFB1 reduced VTN expression and the formation of a VTN-integrin alphaV complex in NPC cells, leading to inhibition of the FAK/Src/ERK signalling pathway.
Insulin resistance and age independently predicted VTN levels. VTN may be a candidate target for the appraisal of hepatic insulin resistance in patients with type 2 diabetes.
The 10 kDa C-terminal fragment of the ECM protein vitronectin (VTN) was then selected as a promising circulating biomarker in discriminating Nonalcoholic steatohepatitis.
The authors observed that exposure of Burkholderia pseudomallei and the closely related yet avirulent Burkholderia thailandensis to human plasma increased epithelial cell invasion by >20 fold. Receptor blocking studies with RGD-domain containing peptide and alphaV beta3 blocking antibody identified complement-activated vitronectin as the factor facilitating this invasion.
Additionally, the authors utilized vitroenctin-derived peptides to map the minimal Rickettsia conorii Adr1/human vitronectin interaction to the C-terminal region of vitronectin.
We show that small N-terminal fragments of VN consistent with processing of the RGD motif are present in liquid biopsies of cancer patients as well as in the urine of healthy individuals.
Serum vitronectin levels are elevated in human glioma, as well as are independently associated with pathologic grade based on WHO classification and 5-year poor prognosis. Moreover, this biomarker significantly discriminates gliomas from controls, other non-glioma brain tumors and other non-tumor neurological diseases, distinguishes high-grade gliomas from low-grade gliomas, and predicts 5-year progression and mortality.
Elevated serum VN levels represented high diagnostic value and had close relation to clinicopathological factors and early recurrence, suggesting that serum VN might be a useful diagnostic and prognostic marker for HCC.
We confirmed increased levels of C1R and VTN in sera from patients with Joint hypermobility syndrome by western blot analyses
This study examines the complexes of PAI-1 with tissue-type and urokinase-type plasminogen activator and vitronectin revealed by changes in the conformation and dynamics of the reactive center loop.
Ail-expressing Yersinia pestis strains bind vitronectin - a host protein with functions in cell attachment, fibrinolysis and inhibition of the complement system.
High expression of VN in tumor cells independently indicated poor clinical prognosis in patients with osteosarcoma.
The mean level of PAI-1 was 23.02 +/- 15 (8.2-71.19) ng/mL and vitronectin was 83.10% +/- 23.77% (12%-126%) in the tumor group.
Bacterial protein-E and host vitronectin play a role in the attachment to bronchial epithelial cells and is also involved in the subsequent intracellular invasion of nontypeable Haemophilus influenzae.
P. aeruginosa isolates obtained from CF patients significantly bound vitronectin. Porin D was defined as a novel P. aeruginosa vitronectin-receptor
Lpd of P. aeruginosa is a surface exposed moonlighting protein that binds two human terminal pathway inhibitors, vitronectin and clusterin
The VN level may be relevant as a clinical biomarker for adverse cardiovascular outcomes not only in patients with ischemic heart disease undergoing coronary interventions.
Vitronectin expression in the airways of subjects with asthma and chronic obstructive pulmonary disease
Gpm1 in Candida albicans attaches to human endothelial cells and to keratinocytes via the adhesive protein vitronectin
The effects of genetic alterations in PAI-1 expression, pharmacologic PAI-1 inhibition and recombinant PAI-1 on smooth muscle cell vitronectin (VN) expression were studied, and vascular VN expression in wild-type and PAI-1-deficient mice was assessed.
this study demonstrates in a mouse infection model that Vn reduces complement-mediated killing of Yersinia enterocolitica O:9 E40 and, thus, improves bacterial survival
the TGF-beta-PAI-1-vitronectin-integrin axis may represent a critical convergence of factors in determining the alveolar epithelial cell apoptotic response during lung injury.
In vtn knockout mice, neuronal differentiation in the cerebellum was suppressed compared with wild-type mice.
Elevated levels of TIMP3 and vitronectin, acting downstream of Notch3(ECD) deposition, play a role in CADASIL, producing divergent influences on early CBF deficits and later white matter lesions.
PAI-1, through its interaction with Vn, exerts multiple deleterious mechanisms to induce AKI.
These data suggest that adhesion to vitronectin allows for the uncoupling of fibronectin fibril formation from downstream signaling events by reducing alpha5beta1 integrin activation and fibronectin fibril extension.
Report role of vitronectin in the regulation of angiogenesis induced by VEGF.
Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages.
the extracellular matrix molecule VN and its neuronal receptor TLCN play a pivotal role in the phosphorylation of ezrin/radixin/moesin proteins and the formation of phagocytic cup-like structures on neuronal dendrites
VN plays a previously unrecognized role in regulating endothelial permeability via conformational- and integrin-dependent effects on VE-cadherin trafficking.
ability of vitronectin to enhance neutrophil viability was dependent on activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 kinases, but not on the p38 kinase
These results demonstrate that vitronectin exerts a deleterious role independently from complement, by directing PAI-dependent fibrinolysis in the glomerular compartment.
the vitronectin-binding capacity of PAI-1 was the primary determinant required for its ability to exacerbate lung scarring induced by intratracheal bleomycin administration
Suggest that despite significant interstitial Vtn deposition in the ureteral obstruction model of chronic kidney disease, its fibrogenic role is either nonessential or redundant.
Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matrices
evaluated the temporal expression pattern of STI1 and Vn and their colocalization with their ligand PrPC, demonstrated that PrPC, STI1, and Vn are coexpressed in most of the embryonic tissues evaluated.
Endogenous vitronectin promotes neointima formation in carotid arteries.
regulation of cell spreading on vitronectin by ERK1 association with alphaVbeta3 integrin
In a carotid artery ligation model, vitronectin (VN) knockout mice generate a larger intima than wild-type as a result of more extensive smooth muscle cell (SMC)proliferation, demonstrating that VN inhibits thrombin-mediated SMC proliferation.
for intact vitronectin the effect of the heparin-binding domain predominates with respect to the signaling events that occur following ligand binding to the alphaVbeta3 integrin
These results imply that the amino acid motif RGD-2 of goat vitronectin is involved in complement C9 binding.
characterization of goat plasma vitronectin
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.
, complement S-protein
, serum spreading factor
, serum-spreading factor
, somatomedin B
, vitronectin (serum spreading factor, somatomedin B, complement S-protein)
, glycoprotein 66
, complement S-protein)