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anti-Human FABP4 Anticorps:
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Human Polyclonal FABP4 Primary Antibody pour EIA, IHC (p) - ABIN3073369
Minkwitz, Faßbender, Kronbach, Wildemann: Longitudinal analysis of osteogenic and angiogenic signaling factors in healing models mimicking atrophic and hypertrophic non-unions in rats. dans PLoS ONE 2016
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Human Polyclonal FABP4 Primary Antibody pour ICC, IF - ABIN4309936
Zhao, Ren, Chen, Zhang, Cheng, Li, Zhang, Gao: Differential expression of lipid metabolism related genes in porcine muscle tissue leading to different intramuscular fat deposition. dans Lipids 2010
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Monoclonal FABP4 Primary Antibody pour ELISA, WB - ABIN533797
Shum, Mackay, Gorgun, Frost, Kumar, Hotamisligil, Rolph: The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. dans The Journal of clinical investigation 2006
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Human Monoclonal FABP4 Primary Antibody pour ELISA, WB - ABIN966115
Smith, Sanders, Thompson, Londos, Kraemer, Bernlohr: Physical association between the adipocyte fatty acid-binding protein and hormone-sensitive lipase: a fluorescence resonance energy transfer analysis. dans The Journal of biological chemistry 2004
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Human Monoclonal FABP4 Primary Antibody pour ELISA, WB - ABIN969125
Ohlsson, Moreira, Gromov, Sauter, Celis: Loss of expression of the adipocyte-type fatty acid-binding protein (A-FABP) is associated with progression of human urothelial carcinomas. dans Molecular & cellular proteomics : MCP 2005
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Human Monoclonal FABP4 Primary Antibody pour ELISA, WB - ABIN969126
Tuncman, Erbay, Hom, De Vivo, Campos, Rimm, Hotamisligil: A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. dans Proceedings of the National Academy of Sciences of the United States of America 2006
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Mouse (Murine) Polyclonal FABP4 Primary Antibody pour ICC, IHC - ABIN1078018
Li, Liang, Wu, Ma, Su: Valproate acid (VPA)-induced dysmetabolic function in clinical and animal studies. dans Clinica chimica acta; international journal of clinical chemistry 2017
Mouse (Murine) Polyclonal FABP4 Primary Antibody pour IHC, WB - ABIN3020736
Zhang, Weng, Shi, Jin: The Engrailed-1 Gene Stimulates Brown Adipogenesis. dans Stem cells international 2016
Human Polyclonal FABP4 Primary Antibody pour IF (p), IHC (p) - ABIN753223
Claycombe, Vomhof-DeKrey, Garcia, Johnson, Uthus, Roemmich et al.: Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (G9a) and reduced FGF21 gene expression in Sprague-Dawley rats fed prenatal low ... dans The Journal of nutritional biochemistry 2016
Circulating A-FABP levels predict the development of subclinical atherosclerosis in type 2 diabetes patients.
Circulating adipose fatty acid binding protein (A-FABP) promotes obesity-associated breast cancer development. A-FABP released by adipose tissue directly targeted mammary tumor cells, enhancing tumor stemness and aggressiveness through activation of the IL-6/STAT3/ALDH1 pathway.
FABP4 concentration is an independent predictor of the progression of carotid atherosclerosis.
Circulating AFABP levels were predictive of incident adverse renal outcomes, even in participants with relatively well-preserved kidney function at baseline, suggesting its potential to be a useful marker for early risk stratification in DKD.
These findings identify A-FABP as a functional marker for protumor macrophages, thus offering a new target for tumor immunotherapy
The emerging oncogenic role of liver endothelial cells through FABP4 in HCC related to MS.
In cardiovascular disease patients, the pericardial cavity is a distinct adipocytokine microenvironment in which especially FABP4 is mainly derived from the heart.
Thus, FABP4 overexpression in hepatic stellate cells may contribute to hepatocarcinogenesis in patients with metabolic risk factors by modulation of inflammatory pathways.
These results demonstrated that loss of A-FABP expression following a long follow-up was predictive of non-muscle invasive bladder cancer progression
Patient serum analysis demonstrated significantly increased FABP4 in those with underlying liver disease, particularly non-alcoholic fatty liver disease and hepatocellular carcinoma. This suggests FABP4, an FABP not normally expressed in the liver, can be synthesized and secreted by hepatocytes and HCC cells, and that FABP4 may play a role in regulating tumour progression in the underlying setting of obesity.
the expression of FABP4 might have a prognostic value in patients with breast cancer
Inhibition of MIR31HG reduced the enrichment of active histone markers, histone H3 lysine 4 trimethylation (H3K4me3) and acetylation (AcH3), in the promoter of the adipogenic-related gene, fatty acid binding protein 4 (FABP4).
the function of FABP4 in cervical cancer and the underlying molecular mechanisms, were investigated.
Elevation of FABP4 is associated with an increased risk of death and poor functional outcome events in patients with type 2 diabetes and acute ischemic stroke and is independent of other established clinical risk predictors and biomarkers
FABP4 shows potential as a novel biomarker for diabetic retinopathy prediction in Chinese patients with type 2 diabetes (T2DM), and strict glycemic control and more frequent retinal examination should be highlighted for T2DM patients with the highest quartile range of FABP4.
association between serum FABP4 concentrations and sarcopenia in chronic hemodialysis patients
intermittent high glucose potentiates A-FABP activation and inflammatory responses via TLR4/p-JNK signaling in THP-1 cells
High serum A-FABP concentration is associated with peripheral arterial disease in women, but not men, with type 2 diabetes mellitus.
FABP4 from adipocytes mediate adipocyte-cholangiocarcinoma interactions that are crucial for the invasion, migration and epithelial-mesenchymal transition of cholangiocarcinoma cells
Compared with the low arterial stiffness group, the high arterial stiffness group had higher values for age, systolic blood pressure, pulse pressure, duration of kidney transplantation and serum A-FABP
Studied SNPs in cattle Fatty Acid Binding Protein 4 (FABP4) in several cattle breeds and evaluated possible associations with regards to meat quality and fat content of the meat.
Overexpressed FABP4 of different genotypes in bovine intramuscular preadipocytes and studied the intracellular localization of FABP4 and the expression levels of lipid metabolism-related genes among different genotypes.
These results provide an important basis for further understanding the regulation of bovine FABP4.
This suggest that FABP4 affects milk yield and milk protein content, both economically important traits, and that further study of this gene is warranted.
Data show that overexpression of cattle adipocyte fatty acid-binding protein (A-FABP)gene promoted fat deposition in the skeletal muscle of transgenic mice.
FABP4 gene frequency and SNP genotypes in Holstein-Friesian cows and its relationship with protein and fat content in milk
polymorphisms can be used to select for milk with lower concentrations of saturated fatty acids and higher concentrations of unsaturated fatty acids
The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.
The results confirm the lack of an association found by many other studies and suggest that these SNPs are not influential on the divergent intramuscular fat levels in the crossbred population tested.
re-sequenced 4.3 kb of the FABP4 gene region in 24 Hanwoo bulls and identified 16 SNPs and 1 microsatellite polymorphism.
The FABP4 gene falls into a suggestive/significant quantitative trait loci interval for beef marbling.
Our findings suggest that the polymorphisms in FABP4 may play a role in determining one of the important genetic factors that influence back fat thickness in beef cattle.
FABP4 I74V polymorphism had a significant effect on palmitoleic acid composition in intramuscular fat.
A splice site single nucleotide polymorphism of the fatty acid binding protein 4 gene appears to be associated with intramuscular fat deposition in longissimus muscle in Australian cattle.
FABP4 gene expression level in adipose tissue was higher than in muscle. In contrast, FABP5 was expressed at low levels in adipocytes and muscle tissues. Low and moderate correlations between FABP4 and FABP5 gene expression were observed in muscle and in backfat, respectively.
the A-FABP gene is strongly related to the development and function of intramuscular fat accretion in pigs.
AFABP is significantly increased in coronary artery in-stent restenosis segments of both diabetic and nondiabetic minipigs.
Thus A-FABP may be a candidate gene or a quantitative trait locus-linked gene associated with meat quality traits.
Monitoring of posttransplant L-FABP plasma levels is a valuable new tool to quantify early the extent of parenchymal cell damage of non-heart-beating donors in liver transplantation.
study suggests that FABP-4 protein content may be a valuable marker of lipid accretion
A study of the mapping characteristics and relationship to body composition of FAT1 and FABP4 in swine is reported.
regenerated coronary endothelial cells exhibit upregulation of adipocyte fatty acid binding protein (A-FABP)
Genetic deletion of A-FABP successfully reduced tumor ALHD1 activation and obesity-associated mammary tumor growth and development in different mouse models.
Fabp4/5 knockout mice demonstrate that glucose is preferentially utilized for biomass synthesis rather than ATP production during pressure-overload-induced cardiac hypertrophy and that the efficient supplementation of energy substrates may restore cardiac dysfunction caused by energy insufficiency.
expression of FABP4 in eosinophils is induced during conditions of inflammation and plays a proinflammatory role in the development of allergic asthma by promoting eosinophil adhesion and migration and contributing to the development of various aspects of airway inflammation.
FABP4/5 have crucial roles in nutrient homeostasis during prolonged fasting for maintaining exercise endurance capacity.
Livers from obese mice, independent of tumour status, exhibited increased FABP4 mRNA and protein expression concomitant with elevated serum FABP4. The data suggest FABP4, an FABP not normally expressed in the liver, can be synthesized and secreted by hepatocytes and hepatocellular carcinoma cells, and that FABP4 may play a role in regulating tumour progression in the underlying setting of obesity.
results proved that the REV-ERB agonism inhibited osteoclastogenesis partially via FABP4 up-regulation.
The findings chart the pathway of FABP4 secretion and provide a potential therapeutic means to control metabolic disorders associated with its dysregulated secretion.
Study in A-FABP knockout mice revealed that A-FABP acts as a physiological stimulator of brown adipose tissue-mediated adaptive thermogenesis.
Fabp4/5 confers protection against metabolic diseases but does not extend lifespan.
Ectopic expression and secretion of FABP4 in vascular endothelial cells contribute to neointima formation after vascular injury.
FABP4 regulates the expression of BLT1R and its downstream signaling via control of oxidative stress in macrophages
Upregulated ROS induced by FABP4 was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction.
Collectively, these results demonstrate that C. pneumoniae exploits host FABP4 to facilitate fat mobilization and intracellular replication in adipocytes. This work uncovers a novel strategy used by intracellular pathogens for acquiring energy via hijacking of the host lipid metabolism pathway.
High Fabp4 expression is associated with Acute myeloid leukemia.
These data suggest that the function of SIRT6 in the Fabp4-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis.
This study demonstrating a FABP4-UCP2 axis with the potential to modulate the microglial inflammatory response.
our data establish A-FABP as a new molecular sensor in triggering macrophage-associated sterile inflammation in obesity.
these data offer a novel pathway whereby FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2 expression.
FABP4 locally produced by epicardial/perivascular fat and macrophages in vascular plaques contributes to the development of coronary atherosclerosis.
endothelial PATZ1 thus potently inhibits endothelial function and angiogenesis via inhibition of FABP4 expression, and abnormal induction of endothelial PATZ1 may contribute to multiple aspects of vascular dysfunction in diabetes
Cloning and characterization of the gene and its homology with other species.
results indicated that an A-FABP gene polymorphism was associated with abdominal fat weight and percentage of abdominal fat, and the A-FABP gene could be a candidate locus or linked to a major gene(s) that affects abdominal fat content in the chicken
FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.
adipocyte lipid-binding protein
, adipocyte-type fatty acid-binding protein
, fatty acid-binding protein 4
, fatty acid-binding protein, adipocyte
, fatty acid binding protein 4, adipocyte
, adipocyte fatty acid binding protein
, adipocyte-type fatty acid binding protein
, Adipocyte-type fatty acid-binding protein
, adipocyte fatty acid-binding protein 4
, Fatty acid-binding protein, adipocyte
, 3T3-L1 lipid-binding protein
, P2 adipocyte protein
, adipocyte protein aP2
, myelin P2 protein homolog
, protein 422