Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher tous les synonymes
Sélectionnez vos espèces d'intérêt
results of this study have shown a significant association between the Trp64Arg polymorphism in ADRB3 gene and the development of overweight and obesity in Saudi populations; It also has an influence on the levels of lipid, insulin, leptin, and glucose
the association between the Arg64 allele of the Trp64Arg polymorphism of ADRB3 gene, FATMAX, and LDL-cholesterol levels should be interpreted with caution, as it may represent a small portion of complex physiological processes related to lipolysis and metabolism lipids.
Nerve fibers expressing immunoreactivity for beta3AR were abundantly found in the mucosa and muscular layers of the human bladder.
The presence of the Trp64Trp genotype is related to higher TAG level in CTDs and reliably predicts hypertriglyceridemia.
The current meta-analysis demonstrated that Trp64Arg polymorphism in ADRB3 was associated with sus- ceptibility to GDM in the European Caucasian population.
The downregulation of beta-ARs after ureter dilation, particularly for beta1-AR and beta3-AR in the muscular layer, suggests a potential compensatory mechanism involving increased contraction of the ureter to push urine through the obstruction.
The mechanism(s) of downstream beta3 adrenoceptor activation in human corpus cavernosum and in penile artery involves CSE-derived H2S and cGMP elevation. In other words, beta3 relaxation does not need the endothelium but is still able to amplify the cGMP signaling through H2S pathway. This study defines a possible novel pharmacological approach in erectile dysfunction treatment.
There were no differences between the distribution of genotypes and the allele frequencies of the PPARG Pro12Ala, and C1431T polymorphisms and the ADRB3 Trp64Arg polymorphism in normo- and hyperglycaemic women.
the mechanism of beta3-AR-mediated upregulation of hepatic apoA-I expression
ADRB3 gene Trp64Arg mutation was significantly associated with an increased predisposition toward hypertension and elevated systolic/diastolic BP in hypertensive patients, suggesting that Trp64Arg is an important hypertension-susceptibility marker.
Studied weight loss in obese patients with Perilipin 4 (PLIN4), Fat mass and obesity-associated (FTO), and beta- adrenergic receptor 3 (ADRB3) polymorphisms treated with Garcinia cambogia/Glucomannan. Results suggest weight loss was attenuated in carriers of PLIN4, FTO, ADRB3 polymorphisms.
Middle-age adult Asians with the ADRB3 rs4994 minor alleles are at increased risk of Type 2 Diabetes (Meta-Analysis).
It has been shown, that presence of one mutant allele of rs9939609 (gene FTO) and rs4994 (gene ADRB3) leads to statistically significant association with obesity.
In mutant group of beta3 adrenoreceptor gene patients have higher insulin and HOMA levels than wild type group, without relation with metabolic
Pharmacological experiments allowed us to demonstrate that these effects were driven by an Erk1/2-mediated activation of the antioxidant transcription factor PPARg. These results suggest that b3-AR protective effects in the myometrium could be due to its dual antioxidant properties.
Inhibition of cholinergic neurotransmission by beta3-adrenoceptors results from adenosine release via equilibrative nucleoside transporters and prejunctional A1-receptor stimulation in urinary bladder.
The minor alleles of ADRB1 and ADRB3 were significantly underrepresented in kinesiology students compared with nonmajors.
ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms may influence weight loss and body composition after controlled weight loss intervention.
body mass index (BMI) >/=25, PRRs of beta-3 adrenergic receptor genotype (Trp/Arg and Arg/Arg) for periodontal disease markers were 0.13 to 0.70, those of PPARgamma genotype (Pro/Pro) were 0.66 to 3.14 and those of the interaction term for the two genotypes were 1.69 to 12.61. Results confirm a positive relation between beta-3 adrenergic receptor genotype & PPAR-gamma genotype
Study reports association of the Arg64 allele of the rs4994 polymorphism of ADRB3 with increased serum urate in Western Polynesian individuals.
In contrast, Adrb3 activation stimulates mature white adipocytes to convert into beige adipocytes.
Specific visible radiation facilitates lipolysis in mature 3T3-L1 adipocytes via rhodopsin-dependent beta3-adrenergic signaling.
beta3-Adrenergic Regulation of EPC Features Through Manipulation of the Bone Marrow MSC Niche.
Findings are of potential physiologic importance as they uncover the antidiuretic effect of beta3-AR stimulation in the kidney.
aerobic exercise training could improve cardiac systolic function and alleviate LV chamber dilation, cardiac fibrosis and hypertrophy in heart failure mice. The mechanism responsible for the protective effects of aerobic exercise is associated with the activation of the beta3-AR-nNOS-NO pathway.
Data (including data from studies in knockout mice) suggest that Adrb3 is dispensable for browning of adipose tissue; here, no differences was observed in cold-induced thermogenic gene expression in brown, white, or beige adipose tissues due to absence of Adrb3; irrespective of duration of cold exposure or sex of mice, no effect of absence of Adrb3 was observed.
injection of a b3-adrenergic receptor (b3-AR) agonist for continuous 5 days increased the number of Ki67-positive brown adipocytes even at Day 1 but not that of SV cells. In addition, the b3-AR antagonist, but not b1-AR antagonist, attenuated the cold exposure-induced increase in the number of Ki67-positive brown adipocytes
ARbeta3 disruption does not affect brown adipose tissue thermogenesis but increases susceptibility to diet-induced obesity by dampening white adipose tissue lipolytic response to adrenergic stimulation.
RIP140 has a unique role in the acute effect of beta-3 adrenergic receptor activation.
Data show that fish oil intake increased oxygen consumption and rectal temperature, with concomitant upregulation of mitochondrial uncoupling protein 1 (UCP1) and beta3 adrenergic receptor (beta3AR).
ADRB3 in perivascular adipose tissue contributes to vascular function in the progression of hypertension.
Theseresultssuggestthat beta3-adrenoceptors are present in colonic Interstitial Cells of Cajal and may play a role in regulating gastrointestinal motility by the inhibition of pacemaker potentials.
role of beta3-adrenoreceptor in myocardial infarction injury via eNOS and nNOS activation
Nitric oxide is a downstream effector of beta3 adrenergic receptors which modulates melanoma cell proliferation.
A single-dose administration of beta3AR agonist before reperfusion decreased infarct size and resulted in a consistent and long-term improvement in cardiac function in mouse model of myocardial ischemia reperfusion injury.
Data suggest that Adrb3 is involved in regulation of pancreatic islet blood flow; hyperlipidemia (triglycerides and free fatty acids) is associated with vagus nerve-dependent increase in pancreatic/islet blood flow and up-regulation of insulin secretion.
Beta3 adrenergic receptor activation lowers blood lipids and glucose which attenuates atherosclerotic plaque formation.
activation of beta-adrenoceptor reduce the plaque area in the thoracic aorta and play an important anti-atherosclerotic role by regulating lipid metabolism disorders and the SR-B1 signal transduction pathway
Beta3-adrenergic receptors modulate vascular endothelial growth factor release in response to hypoxia through the nitric oxide pathway in mouse retinal explants
expression and function of beta(3)-adrenoceptors and beta(2)-adrenoceptors in mouse uterus
Variation in the promoter region of bovine ADRB3 was investigated.
of the beta-adrenergic receptors, adrenergic beta(2)-receptor type was most highly expressed in the mammary gland of dairy cows followed by beta(1) and beta(3)
beta 1,2 and 3-adrenergic receptors in cattle were positively associated with hepatic activities of gluconeogenetic enzymes and with plasma glucose levels, suggesting functional importance
small G protein Rac1 is a key regulator of beta(3)AR signaling in cultured aortic endothelial cells with potentially important implications for the pathways involved in adrenergic modulation of eNOS pathways in the vascular wall
Coronary arteries possess functional beta(3)-adrenoceptors mediating endothelium- and NO-dependent relaxation. Celiprolol exerts a beta(3)-adrenoceptor agonistic activity in this vascular bed.
beta(3)-adrenoceptors are involved in mediating inhibitory effects of beta-adrenoceptor agonists on detrusor contractions via the urothelium in pig bladder dome.
We suggest that ADRB3 polymorphism has the potential to be an important genetic marker for prediction of EMA (eye muscle area)in Duroc pigs.
Up-regulation of cardiac beta3-adrenoreceptor signaling enhances inhibition of left ventricular myocyte contraction and relaxation, exacerbates the dysfunctional calcium channels and may precede the development of alcoholic cardiomyopathy.
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis.
adrenergic, beta-3-, receptor
, beta-3 adrenergic receptor
, beta-3 adrenoceptor
, beta-3 adrenoreceptor
, Beta-3 AR
, Beta-3 adrenoceptor
, beta 3-AR
, beta3-adrenergic receptor
, adrenergic receptor, beta 3
, adrenergic, beta 3, receptor
, beta 3 adrenergic receptor
, beta-3-adrenergic receptor
, beta-3a-adrenergic receptor
, Beta-3 adrenoreceptor
, adrenergic receptor, beta 3b
, adrenoceptor beta 3b
, beta-3-adrenergic receptor b